The Chlamydia trachomatis Type III Secretion Chaperone Slc1 Engages Multiple Early Effectors, Including TepP, a Tyrosine-phosphorylated Protein Required for the Recruitment of CrkI-II to Nascent Inclusions and Innate Immune Signaling

Yi-Shan Chen; Robert J. Bastidas; Hector A. Saka; Victoria K. Carpenter; Kristian L. Richards; Gregory V. Plano; Raphael H. Valdivia

doi:10.1371/journal.ppat.1003954

Loading metrics

Open Access

Peer-reviewed

Research Article

The Chlamydia trachomatis Type III Secretion Chaperone Slc1 Engages Multiple Early Effectors, Including TepP, a Tyrosine-phosphorylated Protein Required for the Recruitment of CrkI-II to Nascent Inclusions and Innate Immune Signaling

Yi-Shan Chen,

Affiliations Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Robert J. Bastidas,

Affiliation Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Hector A. Saka,

Affiliation Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Victoria K. Carpenter,

Affiliation Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Kristian L. Richards,

Affiliation Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Gregory V. Plano,

Affiliation Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Raphael H. Valdivia

* E-mail: Raphael.valdivia@duke.edu

Affiliation Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

The Chlamydia trachomatis Type III Secretion Chaperone Slc1 Engages Multiple Early Effectors, Including TepP, a Tyrosine-phosphorylated Protein Required for the Recruitment of CrkI-II to Nascent Inclusions and Innate Immune Signaling

Yi-Shan Chen,
Robert J. Bastidas,
Hector A. Saka,
Victoria K. Carpenter,
Kristian L. Richards,
Gregory V. Plano,
Raphael H. Valdivia

Published: February 20, 2014
https://doi.org/10.1371/journal.ppat.1003954

Reader Comments

Post a new comment on this article

Correction

Posted by YiShanChen on 05 Mar 2014 at 18:54 GMT

It is G to A transition.
The GEO accession number for microarray data is GSE54336.

Yi-Shan

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Chlamydia infection
Is the Subject Area "Chlamydia infection" applicable to this article?

Thanks for your feedback.
Chlamydia trachomatis
Is the Subject Area "Chlamydia trachomatis" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Chlamydia
Is the Subject Area "Chlamydia" applicable to this article?

Thanks for your feedback.
Immunoprecipitation
Is the Subject Area "Immunoprecipitation" applicable to this article?

Thanks for your feedback.
HeLa cells
Is the Subject Area "HeLa cells" applicable to this article?

Thanks for your feedback.
Secretion
Is the Subject Area "Secretion" applicable to this article?

Thanks for your feedback.
Host cells
Is the Subject Area "Host cells" applicable to this article?

Thanks for your feedback.

The Chlamydia trachomatis Type III Secretion Chaperone Slc1 Engages Multiple Early Effectors, Including TepP, a Tyrosine-phosphorylated Protein Required for the Recruitment of CrkI-II to Nascent Inclusions and Innate Immune Signaling

The Chlamydia trachomatis Type III Secretion Chaperone Slc1 Engages Multiple Early Effectors, Including TepP, a Tyrosine-phosphorylated Protein Required for the Recruitment of CrkI-II to Nascent Inclusions and Innate Immune Signaling

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Correction

Posted by YiShanChen on 05 Mar 2014 at 18:54 GMT