Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

Tara J. Moriarty; M. Ursula Norman; Pina Colarusso; Troy Bankhead; Paul Kubes; George Chaconas

doi:10.1371/journal.ppat.1000090

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Open Access

Peer-reviewed

Research Article

Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

Tara J. Moriarty ,

Contributed equally to this work with: Tara J. Moriarty, M. Ursula Norman

Affiliations Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
⨯
M. Ursula Norman ,

Contributed equally to this work with: Tara J. Moriarty, M. Ursula Norman

Current address: Centre for Inflammatory Diseases, Department of Medicine, Monash University, Victoria, Australia

Affiliation Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada
⨯
Pina Colarusso,

Affiliation Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada
⨯
Troy Bankhead,

Affiliations Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
⨯
Paul Kubes,

Affiliation Department of Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada
⨯
George Chaconas

* E-mail: chaconas@ucalgary.ca

Affiliations Department of Biochemistry & Molecular Biology, University of Calgary, Calgary, Alberta, Canada, Department of Microbiology & Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
⨯

Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

Tara J. Moriarty,
M. Ursula Norman,
Pina Colarusso,
Troy Bankhead,
Paul Kubes,
George Chaconas

Published: June 20, 2008
https://doi.org/10.1371/journal.ppat.1000090

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Well thought out and well executed

Posted by DavidWaldock on 20 Jun 2008 at 15:09 GMT

This stunning experiment quite literally changes the way we think about and visualise spirochaetes and how they interact with their hosts. Well conceptualised, and using contributions from various technical experts, this sets the standard for direct observation of pathogens in vivo.

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Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

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Well thought out and well executed

Posted by DavidWaldock on 20 Jun 2008 at 15:09 GMT