Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization

Joppe W. R Hovius; Marein A. W. P de Jong; Jeroen den Dunnen; Manja Litjens; Erol Fikrig; Tom van der Poll; Sonja I Gringhuis; Teunis B. H Geijtenbeek

doi:10.1371/journal.ppat.0040031

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Research Article

Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization

Joppe W. R Hovius ,

Contributed equally to this work with: Joppe W. R Hovius, Marein A. W. P de Jong

Affiliations Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands , Center for Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, Amsterdam, The Netherlands
⨯
Marein A. W. P de Jong ,

Contributed equally to this work with: Joppe W. R Hovius, Marein A. W. P de Jong

Affiliation Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands
⨯
Jeroen den Dunnen,

Affiliation Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands
⨯
Manja Litjens,

Affiliation Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands
⨯
Erol Fikrig,

Affiliation Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Tom van der Poll,

Affiliations Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands , Center for Infection and Immunity Amsterdam (CINIMA), University of Amsterdam, Amsterdam, The Netherlands
⨯
Sonja I Gringhuis,

Affiliation Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands
⨯
Teunis B. H Geijtenbeek

*To whom correspondence should be addressed. E-mail: T.Geijtenbeek@VUMC.nl

Affiliation Department of Molecular Cell Biology & Immunology, VU Medical Center, Amsterdam, The Netherlands
⨯

Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization

Joppe W. R Hovius,
Marein A. W. P de Jong,
Jeroen den Dunnen,
Manja Litjens,
Erol Fikrig,
Tom van der Poll,
Sonja I Gringhuis,
Teunis B. H Geijtenbeek

Published: February 15, 2008
https://doi.org/10.1371/journal.ppat.0040031

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Posted by CNancarrow on 27 Feb 2008 at 01:23 GMT

molecular mechanism of immunosuppression by tick salivary proteins might provide innovative strategies to combat Lyme disease or other tick-borne illnesses and could lead to the development of novel anti-inflammatory or immunosuppressive drugs.
http://plospathogens.org/article/info:doi/10.1371/journal.ppat.0040031#article1.front1.article-meta1.abstract2.sec1.p1

What other innovative strategies are known to combat Lyme disease and other vector-borne diseases?

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Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization

Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization

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Posted by CNancarrow on 27 Feb 2008 at 01:23 GMT