Soluble Rhesus Lymphocryptovirus gp350 Protects against Infection and Reduces Viral Loads in Animals that Become Infected with Virus after Challenge

Junji Sashihara; Yo Hoshino; J. Jason Bowman; Tammy Krogmann; Peter D. Burbelo; V. McNeil Coffield; Kurt Kamrud; Jeffrey I. Cohen

doi:10.1371/journal.ppat.1002308

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Open Access

Peer-reviewed

Research Article

Soluble Rhesus Lymphocryptovirus gp350 Protects against Infection and Reduces Viral Loads in Animals that Become Infected with Virus after Challenge

Junji Sashihara,

Current address: Department of Pediatrics, Kansai Rousai Hospital, Hyogo, Japan.

Affiliation Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Yo Hoshino,

Current address: Astellas Pharma Inc., Tokyo, Japan.

Affiliation Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
J. Jason Bowman,

Affiliation Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Tammy Krogmann,

Affiliation Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Peter D. Burbelo,

Affiliation Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
V. McNeil Coffield,

Current address: Department of Biology, High Point University, High Point, North Carolina, United States of America.

Affiliation AlphaVax, Inc., Research Triangle Park, North Carolina, United States of America
⨯
Kurt Kamrud,

Current address: Harrisvaccines, Inc. Ames, Iowa, United States of America.

Affiliation AlphaVax, Inc., Research Triangle Park, North Carolina, United States of America
⨯
Jeffrey I. Cohen

* E-mail: jcohen@niaid.nih.gov

Affiliation Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Soluble Rhesus Lymphocryptovirus gp350 Protects against Infection and Reduces Viral Loads in Animals that Become Infected with Virus after Challenge

Junji Sashihara,
Yo Hoshino,
J. Jason Bowman,
Tammy Krogmann,
Peter D. Burbelo,
V. McNeil Coffield,
Kurt Kamrud,
Jeffrey I. Cohen

Published: October 20, 2011
https://doi.org/10.1371/journal.ppat.1002308

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Seeking clarification

Posted by pgs27 on 12 Sep 2012 at 21:00 GMT

Please can the authors say whether the data in fig6 onwards show statistically significant differences between the experimental groups. Apologies if I have missed the information, but I couldn't find it.

No competing interests declared.

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Soluble Rhesus Lymphocryptovirus gp350 Protects against Infection and Reduces Viral Loads in Animals that Become Infected with Virus after Challenge

Soluble Rhesus Lymphocryptovirus gp350 Protects against Infection and Reduces Viral Loads in Animals that Become Infected with Virus after Challenge

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Seeking clarification

Posted by pgs27 on 12 Sep 2012 at 21:00 GMT