TY - JOUR T1 - Novel Transmembrane Receptor Involved in Phagosome Transport of Lysozymes and β-Hexosaminidase in the Enteric Protozoan Entamoeba histolytica A1 - Furukawa, Atsushi A1 - Nakada-Tsukui, Kumiko A1 - Nozaki, Tomoyoshi Y1 - 2012/02/23 N2 - Author Summary Phagocytosis is the cellular process of engulfing solid particles to form an internal phagosome in protozoa, algae, and professional phagocytes of multicellular eukaryotic organisms. In phagocytic protozoa, phagocytosis is involved in the acquisition of nutrients, and the evasion from the host immune system and inflammation. While hydrolytic enzymes that are essential for the efficient and regulated degradation of phagocytosed particles, such as bacteria, fungi, and eukaryotic organisms, have been characterized, the mechanisms of the transport of these proteins are poorly understood. In the present study, we have demonstrated, for the first time, the molecular mechanisms of how the digestive enzymes are transported to phagosomes. Understanding of such mechanisms of the transport of phagosomal proteins at the molecular level may lead to the identification of a novel target for the development of new preventive measures against parasitic infections caused by phagocytic protozoa. JF - PLOS Pathogens JA - PLOS Pathogens VL - 8 IS - 2 UR - https://doi.org/10.1371/journal.ppat.1002539 SP - e1002539 EP - PB - Public Library of Science M3 - doi:10.1371/journal.ppat.1002539 ER -