About the Authors

Magali Roques

Contributed equally to this work with: Magali Roques, Richard J. Wall, Alexander P. Douglass, Abhinay Ramaprasad

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Richard J. Wall

Contributed equally to this work with: Magali Roques, Richard J. Wall, Alexander P. Douglass, Abhinay Ramaprasad

Current Address: Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Alexander P. Douglass

Contributed equally to this work with: Magali Roques, Richard J. Wall, Alexander P. Douglass, Abhinay Ramaprasad

Current Address: Conway Institute, University College Dublin, Dublin 4, Republic of Ireland

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Abhinay Ramaprasad

Contributed equally to this work with: Magali Roques, Richard J. Wall, Alexander P. Douglass, Abhinay Ramaprasad

Affiliation Biological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia

David J. P. Ferguson

Affiliation Nuffield Department of Clinical Laboratory Science, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

Mbinda L. Kaindama

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Lorenzo Brusini

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Nimitray Joshi

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Zineb Rchiad

Affiliation Biological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia

Declan Brady

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

David S. Guttery

Current Address: Department of Cancer Studies, University of Leicester, Robert Kilpatrick Building, PO Box 65, Leicester Royal Infirmary, Leicester, United Kingdom

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Sally P. Wheatley

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Hiroyuki Yamano

Affiliation UCL Cancer Institute, University College London, London, United Kingdom

Anthony A. Holder

Affiliation Mill Hill Laboratory, The Francis Crick Institute, Mill Hill, London, United Kingdom

Arnab Pain

Current Address: Center for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, N20 W10 Kita-ku, Sapporo, 001–0020 Japan

Affiliation Biological and Environmental Sciences and Engineering (BESE) Division, King Abdullah University of Science and Technology, Thuwal, Kingdom of Saudi Arabia

Bill Wickstead

bill.wickstead@nottingham.ac.uk (BW); rita.tewari@nottingham.ac.uk (RT)

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Rita Tewari

bill.wickstead@nottingham.ac.uk (BW); rita.tewari@nottingham.ac.uk (RT)

Affiliation School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BW RT. Performed the experiments: RT MR RJW AR DJPF MLK LB NJ ZR DB DSG SPW HY BW. Analyzed the data: RT BW RJW MR AAH AP DJPF SPW HY AR DSG LB. Contributed reagents/materials/analysis tools: DJPF AP HY AAH BW RT. Wrote the paper: MR RJW BW RT. Performed the Functional and GFP tagging experiments: RT MR RJW LB MLK DB DSG SPW. Phyogenetics analysis: APD BW. RNAseq experiment: AR ZR AP. QPCR analysis: NJ MR RJW. Yeast complementation experiment: HY. Electron microscopy experiment: DJPF.