About the Authors
- Edward J. D. Greenwood
-
Current address: Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
- Fabian Schmidt
-
Current address: Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America
Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
- Ivanela Kondova
-
Affiliation Division of Pathology and Microbiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
- Henk Niphuis
-
Affiliation Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
- Vida L. Hodara
-
Affiliations Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America, Southwest National Primate Research Center, San Antonio, Texas, United States of America
- Leah Clissold
-
Affiliation The Genome Analysis Centre (TGAC), Norwich, United Kingdom
- Kirsten McLay
-
Affiliation The Genome Analysis Centre (TGAC), Norwich, United Kingdom
- Bernadette Guerra
-
Affiliation Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
- Sharon Redrobe
-
Affiliation Twycross Zoo - East Midland Zoological Society, Atherstone, United Kingdom
- Luis D. Giavedoni
-
Affiliations Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America, Southwest National Primate Research Center, San Antonio, Texas, United States of America
- Robert E. Lanford
-
Affiliations Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America, Southwest National Primate Research Center, San Antonio, Texas, United States of America
- Krishna K. Murthy
-
Current address: IDS Consulting, San Antonio, Texas, United States of America
Affiliation Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
- François Rouet
-
Current address: Unité VIH/Hépatites, Institut Pasteur du Cambodge, Phnom-Penh, Cambodia
Affiliation Laboratoire de Rétrovirologie, Centre International de Recherches Médicales de Franceville, Franceville, Gabon
- Jonathan L. Heeney
-
* E-mail: jlh66@cam.ac.uk
Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: EJDG FS JLH. Performed the experiments: EJDG FS BG REL HN VLH. Analyzed the data: EJDG VLH IK. Contributed reagents/materials/analysis tools: KKM LDG FR SR. Wrote the paper: EJDG JLH. Planned original SIVcpz infection experiments [16], carried out between 1995 and 1997: JLH KKM. Instigated the retrospective analysis of samples and follow-up of living animals in 2008: EJDG FS JLH. Analysis of retrospective samples, including ELISAs for soluble markers, preparation of samples for transcriptomics analysis, bioinformatic analysis of transcriptomics results and quantitative image analysis: EJDG. qRT-PCR assay designed: EJDG FS. qRT-PCR assay carried out: EJDG BG REL. Statistical analysis, preparation of figures and manuscript and co-ordination of author contributions: EJDG. Immunohistochemical stainings were carried out by the histopathology department of the Department of Veterinary Medicine under direction of: EJDG FS. Immunopathological analysis of histological materials: IK. Flow cytometric data acquisition and analysis: EJDG HN VLH LDG. Transcriptomics library construction and sequencing: LC KM.