About the Authors

Edward J. D. Greenwood

Current address: Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

Fabian Schmidt

Current address: Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York, United States of America

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

Ivanela Kondova

Affiliation Division of Pathology and Microbiology, Biomedical Primate Research Centre, Rijswijk, The Netherlands

Henk Niphuis

Affiliation Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands

Vida L. Hodara

Affiliations Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America, Southwest National Primate Research Center, San Antonio, Texas, United States of America

Leah Clissold

Affiliation The Genome Analysis Centre (TGAC), Norwich, United Kingdom

Kirsten McLay

Affiliation The Genome Analysis Centre (TGAC), Norwich, United Kingdom

Bernadette Guerra

Affiliation Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America

Sharon Redrobe

Affiliation Twycross Zoo - East Midland Zoological Society, Atherstone, United Kingdom

Luis D. Giavedoni

Affiliations Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America, Southwest National Primate Research Center, San Antonio, Texas, United States of America

Robert E. Lanford

Affiliations Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America, Southwest National Primate Research Center, San Antonio, Texas, United States of America

Krishna K. Murthy

Current address: IDS Consulting, San Antonio, Texas, United States of America

Affiliation Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, Texas, United States of America

François Rouet

Current address: Unité VIH/Hépatites, Institut Pasteur du Cambodge, Phnom-Penh, Cambodia

Affiliation Laboratoire de Rétrovirologie, Centre International de Recherches Médicales de Franceville, Franceville, Gabon

Jonathan L. Heeney

jlh66@cam.ac.uk

Affiliation Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EJDG FS JLH. Performed the experiments: EJDG FS BG REL HN VLH. Analyzed the data: EJDG VLH IK. Contributed reagents/materials/analysis tools: KKM LDG FR SR. Wrote the paper: EJDG JLH. Planned original SIVcpz infection experiments [16], carried out between 1995 and 1997: JLH KKM. Instigated the retrospective analysis of samples and follow-up of living animals in 2008: EJDG FS JLH. Analysis of retrospective samples, including ELISAs for soluble markers, preparation of samples for transcriptomics analysis, bioinformatic analysis of transcriptomics results and quantitative image analysis: EJDG. qRT-PCR assay designed: EJDG FS. qRT-PCR assay carried out: EJDG BG REL. Statistical analysis, preparation of figures and manuscript and co-ordination of author contributions: EJDG. Immunohistochemical stainings were carried out by the histopathology department of the Department of Veterinary Medicine under direction of: EJDG FS. Immunopathological analysis of histological materials: IK. Flow cytometric data acquisition and analysis: EJDG HN VLH LDG. Transcriptomics library construction and sequencing: LC KM.