TLR2 Signaling Decreases Transmission of Streptococcus pneumoniae by Limiting Bacterial Shedding in an Infant Mouse Influenza A Co-infection Model

Aimee L. Richard; Steven J. Siegel; Jan Erikson; Jeffrey N. Weiser

doi:10.1371/journal.ppat.1004339

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Open Access

Peer-reviewed

Research Article

TLR2 Signaling Decreases Transmission of Streptococcus pneumoniae by Limiting Bacterial Shedding in an Infant Mouse Influenza A Co-infection Model

Aimee L. Richard,

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Steven J. Siegel,

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Jan Erikson,

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯
Jeffrey N. Weiser

* E-mail: weiser@mail.med.upenn.edu

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

TLR2 Signaling Decreases Transmission of Streptococcus pneumoniae by Limiting Bacterial Shedding in an Infant Mouse Influenza A Co-infection Model

Aimee L. Richard,
Steven J. Siegel,
Jan Erikson,
Jeffrey N. Weiser

Published: August 28, 2014
https://doi.org/10.1371/journal.ppat.1004339

About the Authors

Aimee L. Richard

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Steven J. Siegel

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Jan Erikson

Affiliation The Wistar Institute, Philadelphia, Pennsylvania, United States of America

Jeffrey N. Weiser

* E-mail: weiser@mail.med.upenn.edu

Affiliation Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ALR SJS JE JNW. Performed the experiments: ALR SJS. Analyzed the data: ALR SJS JNW. Contributed reagents/materials/analysis tools: JE. Wrote the paper: ALR JNW.

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Mouse models
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Pneumococcus
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Influenza
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Inflammation
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Neutrophils
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Bacterial pathogens
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Co-infections
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Nasopharynx
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