About the Authors

Lena Serghides

lena.serghides@utoronto.ca

Affiliations Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada, SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada

Chloe R. McDonald

Contributed equally to this work with: Chloe R. McDonald, Ziyue Lu

Affiliations SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Ziyue Lu

Contributed equally to this work with: Chloe R. McDonald, Ziyue Lu

Affiliations SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Miriam Friedel

Affiliation Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada

Cheryl Cui

Affiliation Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Keith T. Ho

Affiliation Department of Physiology, University of Toronto, Toronto, Ontario, Canada

Howard T. J. Mount

Affiliations Department of Physiology, University of Toronto, Toronto, Ontario, Canada, Department of Psychiatry, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

John G. Sled

Affiliations Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

Kevin C. Kain

Affiliations Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada, SA Rotman Laboratories, Sandra Rotman Centre for Global Health, University Health Network, Toronto, Ontario, Canada, Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Competing Interests

I have read the journal's policy and have the following conflicts: The University Health Network holds intellectual property pertaining to the use of PPARγ agonists for the treatment of severe malaria. The authors have no other financial interests related to this work. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LS CRM KCK. Performed the experiments: LS CRM ZL CC MF. Analyzed the data: LS CRM ZL MF JGS KCK. Contributed reagents/materials/analysis tools: JGS KTH HTJM. Wrote the paper: LS KCK.