Regulation of Innate Responses during Pre-patent Schistosome Infection Provides an Immune Environment Permissive for Parasite Development

Diana K. Riner; Christine E. Ferragine; Sean K. Maynard; Stephen J. Davies

doi:10.1371/journal.ppat.1003708

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Open Access

Peer-reviewed

Research Article

Regulation of Innate Responses during Pre-patent Schistosome Infection Provides an Immune Environment Permissive for Parasite Development

Diana K. Riner,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Christine E. Ferragine,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Sean K. Maynard,

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯
Stephen J. Davies

* E-mail: stephen.davies@usuhs.edu

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
⨯

Regulation of Innate Responses during Pre-patent Schistosome Infection Provides an Immune Environment Permissive for Parasite Development

Diana K. Riner,
Christine E. Ferragine,
Sean K. Maynard,
Stephen J. Davies

Published: October 10, 2013
https://doi.org/10.1371/journal.ppat.1003708

About the Authors

Diana K. Riner

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Christine E. Ferragine

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Sean K. Maynard

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Stephen J. Davies

* E-mail: stephen.davies@usuhs.edu

Affiliation Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DKR SJD. Performed the experiments: DKR CEF SKM. Analyzed the data: DKR SJD. Wrote the paper: DKR SJD.

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Parasitic diseases
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Schistosoma
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Inflammation
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Immune response
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Macrophages
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Eggs
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Necrosis
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Transcriptional control
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