About the Authors
- Emmanuel A. Asante
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- Jacqueline M. Linehan
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- Michelle Smidak
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- Andrew Tomlinson
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- Andrew Grimshaw
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- Asif Jeelani
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- Tatiana Jakubcova
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- Shyma Hamdan
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- Caroline Powell
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- Sebastian Brandner
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- Jonathan D. F. Wadsworth
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Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
- John Collinge
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* E-mail: j.collinge@prion.ucl.ac.uk
Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom
Competing Interests
JC and JW are shareholders and JC is a director of D-Gen Limited, an academic spin-out company working in the field of prion disease diagnosis, decontamination and therapeutics. D-Gen markets one of the routine antibodies (ICSM 35) used in this study. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: EAA JDFW JC. Performed the experiments: EAA JML MS AT AG AJ TJ SH CP SB. Analyzed the data: EAA MS SB JDFW JC. Contributed reagents/materials/analysis tools: EAA JDFW SB JC. Wrote the paper: EAA JDFW JC.