About the Authors

Emmanuel A. Asante

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Jacqueline M. Linehan

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Michelle Smidak

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Andrew Tomlinson

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Andrew Grimshaw

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Asif Jeelani

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Tatiana Jakubcova

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Shyma Hamdan

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Caroline Powell

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Sebastian Brandner

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Jonathan D. F. Wadsworth

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

John Collinge

j.collinge@prion.ucl.ac.uk

Affiliation Medical Research Council Prion Unit and Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, United Kingdom

Competing Interests

JC and JW are shareholders and JC is a director of D-Gen Limited, an academic spin-out company working in the field of prion disease diagnosis, decontamination and therapeutics. D-Gen markets one of the routine antibodies (ICSM 35) used in this study. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EAA JDFW JC. Performed the experiments: EAA JML MS AT AG AJ TJ SH CP SB. Analyzed the data: EAA MS SB JDFW JC. Contributed reagents/materials/analysis tools: EAA JDFW SB JC. Wrote the paper: EAA JDFW JC.