Myxoma Virus Protein M029 Is a Dual Function Immunomodulator that Inhibits PKR and Also Conscripts RHA/DHX9 to Promote Expanded Host Tropism and Viral Replication

Masmudur M. Rahman; Jia Liu; Winnie M. Chan; Stefan Rothenburg; Grant McFadden

doi:10.1371/journal.ppat.1003465

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Peer-reviewed

Research Article

Myxoma Virus Protein M029 Is a Dual Function Immunomodulator that Inhibits PKR and Also Conscripts RHA/DHX9 to Promote Expanded Host Tropism and Viral Replication

Masmudur M. Rahman,

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Jia Liu,

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Winnie M. Chan,

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯
Stefan Rothenburg,

Affiliation Laboratory for Host-Specific Virology, Division of Biology, Kansas State University, Manhattan, Kansas, United States of America
⨯
Grant McFadden

* E-mail: grantmcf@ufl.edu

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America
⨯

Myxoma Virus Protein M029 Is a Dual Function Immunomodulator that Inhibits PKR and Also Conscripts RHA/DHX9 to Promote Expanded Host Tropism and Viral Replication

Masmudur M. Rahman,
Jia Liu,
Winnie M. Chan,
Stefan Rothenburg,
Grant McFadden

Published: July 4, 2013
https://doi.org/10.1371/journal.ppat.1003465

About the Authors

Masmudur M. Rahman

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America

Jia Liu

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America

Winnie M. Chan

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America

Stefan Rothenburg

Affiliation Laboratory for Host-Specific Virology, Division of Biology, Kansas State University, Manhattan, Kansas, United States of America

Grant McFadden

* E-mail: grantmcf@ufl.edu

Affiliation Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, United States of America

Competing Interests

The authors have declared that no competing interest exist.

Author Contributions

Conceived and designed the experiments: MMR GM. Performed the experiments: MMR JL WMC. Analyzed the data: MMR GM. Contributed reagents/materials/analysis tools: MMR SR. Wrote the paper: MMR GM.

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Viral replication
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Rabbits
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Small interfering RNA
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Fluorescence imaging
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Myxoma virus
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Antibodies
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Ribonucleases
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Transfection
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