About the Authors

David J. Stanley

Contributed equally to this work with: David J. Stanley, Koen Bartholomeeusen

Affiliations Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America, Graduate Program in Biophysics, University of California, San Francisco, San Francisco, California, United States of America

Koen Bartholomeeusen

Contributed equally to this work with: David J. Stanley, Koen Bartholomeeusen

Affiliation Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America

David C. Crosby

Affiliation Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

Dong Young Kim

Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

Eunju Kwon

Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

Linda Yen

Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

Nathalie Caretta Cartozo

Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

Ming Li

Affiliation Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

Stefanie Jäger

Affiliation Department of Molecular and Cellular Pharmacology, University of California, San Francisco, San Francisco, California, United States of America

Jeremy Mason-Herr

Affiliation Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

Fumiaki Hayashi

Affiliation RIKEN Systems and Structural Biology Center, Tsurumi, Yokohama, Japan

Shigeyuki Yokoyama

Affiliations RIKEN Systems and Structural Biology Center, Tsurumi, Yokohama, Japan, Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan

Nevan J. Krogan

Affiliations Department of Molecular and Cellular Pharmacology, University of California, San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, QB3, University of California, San Francisco, San Francisco, California, United States of America, J. David Gladstone Institutes, San Francisco, California, United States of America

Reuben S. Harris

Affiliation Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America

Boris Matija Peterlin

Affiliation Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America

John D. Gross

jdgross@cgl.ucsf.edu

Affiliations Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America, California Institute for Quantitative Biosciences, QB3, University of California, San Francisco, San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJS KB DCC NJK RSH BMP JDG. Performed the experiments: DJS KB DCC LY EK ML NCC SJ FH. Analyzed the data: DJS KB DCC NCC BMP JDG. Contributed reagents/materials/analysis tools: ML DYK SJ JMH FH SY RSH NJK. Wrote the paper: DJS KB BMP JDG.