About the Authors

S. Kyle Austin

Affiliation Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

Kimberly A. Dowd

Affiliation Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Bimmi Shrestha

Affiliation Department of Medicine (Infectious Diseases), Washington University School of Medicine, Saint Louis, Missouri, United States of America

Christopher A. Nelson

Affiliation Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

Melissa A. Edeling

Affiliation Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

Syd Johnson

Affiliation MacroGenics, Rockville, Maryland, United States of America

Theodore C. Pierson

Affiliation Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Michael S. Diamond

diamond@borcim.wustl.edu (MSD); fremont@wustl.edu (DHF)

Affiliations Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Medicine (Infectious Diseases), Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America

Daved H. Fremont

diamond@borcim.wustl.edu (MSD); fremont@wustl.edu (DHF)

Affiliations Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, Missouri, United States of America, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, Saint Louis, Missouri, United States of America

Competing Interests

MacroGenics has licensed some of the anti-DENV antibodies described in the work from Washington University. Syd Johnson is an employee of MacroGenics. Michael Diamond is a paid consultant of MacroGenics. None of the other authors have financial interests related to this work. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SKA TCP MSD DHF. Performed the experiments: SKA KAD BS MAE DHF. Analyzed the data: SKA CAN TCP MSD DHF. Contributed reagents/materials/analysis tools: SJ MAE. Wrote the paper: SKA TCP MSD DHF.