About the Authors

Keith P. Romano

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Akbar Ali

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Cihan Aydin

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Djade Soumana

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Ayşegül Özen

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Laura M. Deveau

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Casey Silver

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Hong Cao

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Alicia Newton

Affiliation Monogram Biosciences, San Francisco, California, United States of America

Christos J. Petropoulos

Affiliation Monogram Biosciences, San Francisco, California, United States of America

Wei Huang

Affiliation Monogram Biosciences, San Francisco, California, United States of America

Celia A. Schiffer

Celia.Schiffer@umassmed.edu

Affiliation Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Competing Interests

Alicia Newton, Christos J. Petropoulos, and Wei Huang are employees of Monogram Biosciences. From roughly 2008 - August 2010 Celia Schiffer served as a consultant to Monogram Biosciences, on topics unrelated to this research and thus has no competing interest. Since the completion of this research project Celia Schiffer has received small "Sponsored Research Grants" from Avila (CelGene) and Merck. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CAS KPR AA. Performed the experiments: KPR AA CA DS AO LMD CS HC AN WH. Analyzed the data: KPR AA CAS. Contributed reagents/materials/analysis tools: KPR AA CA DS AO LMD CS HC AN CJP WH. Wrote the paper: KPR AA CAS.