About the Authors

Seong Gyu Jeon

Contributed equally to this work with: Seong Gyu Jeon, Hisako Kayama

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Hisako Kayama

Contributed equally to this work with: Seong Gyu Jeon, Hisako Kayama

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Yoshiyasu Ueda

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Takuya Takahashi

Affiliation Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan

Takashi Asahara

Affiliation Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan

Hirokazu Tsuji

Affiliation Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan

Noriko M. Tsuji

Affiliation Age Dimension Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

Hiroshi Kiyono

Affiliations Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan, Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Ji Su Ma

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Takashi Kusu

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Ryu Okumura

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Hiromitsu Hara

Affiliation Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan

Hiroki Yoshida

Affiliation Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan

Masahiro Yamamoto

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Koji Nomoto

Affiliation Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan

Kiyoshi Takeda

ktakeda@ongene.med.osaka-u.ac.jp

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: K. Takeda. Performed the experiments: S.G. Jeon, H. Kayama, Y. Ueda, J.S. Ma, T. Kusu, R. Okumura. Analyzed the data: S.G. Jeon, H. Kayama, M. Yamamoto, K. Takeda. Contributed reagents/materials/analysis tools: T. Takahashi, T. Asahara, H. Tsuji, N.M. Tsuji, H. Kiyono, H. Hara, H. Yoshida, K. Nomoto. Wrote the paper: K. Takeda.