The Haemophilus influenzae HMW1C Protein Is a Glycosyltransferase That Transfers Hexose Residues to Asparagine Sites in the HMW1 Adhesin

Susan Grass; Cheryl F. Lichti; R. Reid Townsend; Julia Gross; Joseph W. St. Geme III

doi:10.1371/journal.ppat.1000919

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Peer-reviewed

Research Article

The Haemophilus influenzae HMW1C Protein Is a Glycosyltransferase That Transfers Hexose Residues to Asparagine Sites in the HMW1 Adhesin

Susan Grass,

Affiliation Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Cheryl F. Lichti,

Affiliation Department of Medicine Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
R. Reid Townsend,

Affiliations Department of Medicine Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Julia Gross,

Affiliation Department of Medicine Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Joseph W. St. Geme III

Affiliations Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

The Haemophilus influenzae HMW1C Protein Is a Glycosyltransferase That Transfers Hexose Residues to Asparagine Sites in the HMW1 Adhesin

Susan Grass,
Cheryl F. Lichti,
R. Reid Townsend,
Julia Gross,
Joseph W. St. Geme III

Published: May 27, 2010
https://doi.org/10.1371/journal.ppat.1000919

About the Authors

Susan Grass: Affiliation Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America
Cheryl F. Lichti: Affiliation Department of Medicine Washington University School of Medicine, St. Louis, Missouri, United States of America
R. Reid Townsend: Affiliations Department of Medicine Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Julia Gross: Affiliation Department of Medicine Washington University School of Medicine, St. Louis, Missouri, United States of America
Joseph W. St. Geme III: Affiliations Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SG RRT JWSG. Performed the experiments: SG CFL JG JWSG. Analyzed the data: SG CFL RRT JG JWSG. Wrote the paper: CFL RRT JG JWSG.

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Glycosylation
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Asparagine
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Haemophilus influenzae
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Glucose
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Hexoses
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Glycosyltransferases
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Galactose
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Carbohydrates
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