About the Authors
- Alex Butschi
-
Contributed equally to this work with: Alex Butschi, Alexander Titz, Martin A. Wälti
Affiliation Institute of Molecular Biology, University of Zürich, Zürich, Switzerland
- Alexander Titz
-
Contributed equally to this work with: Alex Butschi, Alexander Titz, Martin A. Wälti
Affiliation Institute of Microbiology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland
- Martin A. Wälti
-
Contributed equally to this work with: Alex Butschi, Alexander Titz, Martin A. Wälti
Current address: Institute of Zoology, University of Zürich, Zürich, Switzerland
Affiliation Institute of Microbiology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland
- Vincent Olieric
-
Affiliation Swiss Light Source (SLS), Paul-Scherrer-Institute (PSI), Villigen, Switzerland
- Katharina Paschinger
-
Affiliation Department of Chemistry, University of Natural Resources and Applied Life Sciences (BOKU), Vienna, Austria
- Katharina Nöbauer
-
Affiliation VetOMICS Core Facility for Proteomics & Metabolomics Studies, University of Veterinary Medicine, Vienna, Austria
- Xiaoqiang Guo
-
Current address: Max Planck Institute of Colloids and Interfaces, Potsdam-Golm, Germany
Affiliation Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich, Switzerland
- Peter H. Seeberger
-
Current address: Max Planck Institute of Colloids and Interfaces, Potsdam-Golm, Germany
Affiliation Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich, Switzerland
- Iain B. H. Wilson
-
Affiliation Department of Chemistry, University of Natural Resources and Applied Life Sciences (BOKU), Vienna, Austria
- Markus Aebi
-
Affiliation Institute of Microbiology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland
- Michael O. Hengartner
-
Affiliation Institute of Molecular Biology, University of Zürich, Zürich, Switzerland
- Markus Künzler
-
* E-mail: markus.kuenzler@micro.biol.ethz.ch
Affiliation Institute of Microbiology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: IBHW MA MOH MK. Performed the experiments: AB AT MAW VO KP XG. Analyzed the data: AB AT MAW VO KP XG. Contributed reagents/materials/analysis tools: VO KN PHS IBHW MA MOH. Wrote the paper: MK. Performed the C. elegans toxicity assays, the Mos1 screen and the microscopy: AB. Performed the N-glycan analysis (with help of KP and KN) and the ITC measurements (with help of MAW): AT. Discovered the nematotoxicity of CGL2, purified CGL2 and produced the CGL2 crystals: MAW. Determined the X-ray structure: VO. Synthesized the trisaccharide: XG.