About the Authors

Alex Butschi

Contributed equally to this work with: Alex Butschi, Alexander Titz, Martin A. Wälti

Affiliation Institute of Molecular Biology, University of Zürich, Zürich, Switzerland

Alexander Titz

Contributed equally to this work with: Alex Butschi, Alexander Titz, Martin A. Wälti

Affiliation Institute of Microbiology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland

Martin A. Wälti

Contributed equally to this work with: Alex Butschi, Alexander Titz, Martin A. Wälti

Address Current address: Institute of Zoology, University of Zürich, Zürich, Switzerland

Affiliation Institute of Microbiology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland

Vincent Olieric

Affiliation Swiss Light Source (SLS), Paul-Scherrer-Institute (PSI), Villigen, Switzerland

Katharina Paschinger

Affiliation Department of Chemistry, University of Natural Resources and Applied Life Sciences (BOKU), Vienna, Austria

Katharina Nöbauer

Affiliation VetOMICS Core Facility for Proteomics & Metabolomics Studies, University of Veterinary Medicine, Vienna, Austria

Xiaoqiang Guo

Address Current address: Max Planck Institute of Colloids and Interfaces, Potsdam-Golm, Germany

Affiliation Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich, Switzerland

Peter H. Seeberger

Address Current address: Max Planck Institute of Colloids and Interfaces, Potsdam-Golm, Germany

Affiliation Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich, Switzerland

Iain B. H. Wilson

Affiliation Department of Chemistry, University of Natural Resources and Applied Life Sciences (BOKU), Vienna, Austria

Markus Aebi

Affiliation Institute of Microbiology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland

Michael O. Hengartner

Affiliation Institute of Molecular Biology, University of Zürich, Zürich, Switzerland

Markus Künzler

markus.kuenzler@micro.biol.ethz.ch

Affiliation Institute of Microbiology, Swiss Federal Institute of Technology (ETH) Zürich, Zürich, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IBHW MA MOH MK. Performed the experiments: AB AT MAW VO KP XG. Analyzed the data: AB AT MAW VO KP XG. Contributed reagents/materials/analysis tools: VO KN PHS IBHW MA MOH. Wrote the paper: MK. Performed the C. elegans toxicity assays, the Mos1 screen and the microscopy: AB. Performed the N-glycan analysis (with help of KP and KN) and the ITC measurements (with help of MAW): AT. Discovered the nematotoxicity of CGL2, purified CGL2 and produced the CGL2 crystals: MAW. Determined the X-ray structure: VO. Synthesized the trisaccharide: XG.