Early Steps of HIV-1 Fusion Define the Sensitivity to Inhibitory Peptides That Block 6-Helix Bundle Formation

Kosuke Miyauchi; Michael M. Kozlov; Gregory B. Melikyan

doi:10.1371/journal.ppat.1000585

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Open Access

Peer-reviewed

Research Article

Early Steps of HIV-1 Fusion Define the Sensitivity to Inhibitory Peptides That Block 6-Helix Bundle Formation

Kosuke Miyauchi,

Current address: AIDS Research Center, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan

Affiliation Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Michael M. Kozlov,

Affiliation Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Gregory B. Melikyan

* E-mail: gmelikian@ihv.umaryland.edu

Affiliation Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯

Early Steps of HIV-1 Fusion Define the Sensitivity to Inhibitory Peptides That Block 6-Helix Bundle Formation

Kosuke Miyauchi,
Michael M. Kozlov,
Gregory B. Melikyan

Published: September 18, 2009
https://doi.org/10.1371/journal.ppat.1000585

About the Authors

Kosuke Miyauchi

Current address: AIDS Research Center, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan

Affiliation Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Michael M. Kozlov

Affiliation Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Gregory B. Melikyan

* E-mail: gmelikian@ihv.umaryland.edu

Affiliation Institute of Human Virology and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MMK GBM. Performed the experiments: KM. Analyzed the data: KM MMK GBM. Wrote the paper: GBM.

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Cell fusion
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HIV-1
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Coreceptors
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Endocytosis
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CD coreceptors
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Membrane fusion
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HIV
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Cell binding
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