About the Authors

Hisako Kayama

Contributed equally to this work with: Hisako Kayama, Ritsuko Koga

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

Ritsuko Koga

Contributed equally to this work with: Hisako Kayama, Ritsuko Koga

Affiliation Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

Koji Atarashi

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

Megumi Okuyama

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

Taishi Kimura

Affiliation Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

Tak W. Mak

Affiliation Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada, and Department of Medical Biophysics, Advanced Medical Discovery Institute, University of Toronto, Toronto, Ontario Canada

Satoshi Uematsu

Affiliations WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

Shizuo Akira

Affiliations WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

Hiroshi Takayanagi

Affiliation Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

Kenya Honda

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

Masahiro Yamamoto

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

Kiyoshi Takeda

ktakeda@ongene.med.osaka-u.ac.jp

Affiliations Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HK RK KT. Performed the experiments: HK RK KA TK. Analyzed the data: HK RK KH MY. Contributed reagents/materials/analysis tools: HK RK MO TWM SU SA HT. Wrote the paper: HK KT.