iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice

Carl De Trez; Stefan Magez; Shizuo Akira; Bernhard Ryffel; Yves Carlier; Eric Muraille

doi:10.1371/journal.ppat.1000494

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Open Access

Peer-reviewed

Research Article

iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice

Carl De Trez,

Affiliation Laboratoire de Parasitologie, Faculté de Médecine, Université Libre de Bruxelles, Brussels, Belgium
⨯
Stefan Magez,

Affiliation Department of Molecular and Cellular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Brussels, Belgium
⨯
Shizuo Akira,

Affiliation Department of Host Defense, Research Institute for Microbial Diseases, Osaka University Yamadaoka, Suita City, Osaka, Japan
⨯
Bernhard Ryffel,

Affiliation University of Orleans, Transgenose Institute, CNRS, UMR 6218, Orleans, France
⨯
Yves Carlier,

Affiliation Laboratoire de Parasitologie, Faculté de Médecine, Université Libre de Bruxelles, Brussels, Belgium
⨯
Eric Muraille

* E-mail: emuraille@hotmail.com

Affiliation Laboratoire de Parasitologie, Faculté de Médecine, Université Libre de Bruxelles, Brussels, Belgium
⨯

iNOS-Producing Inflammatory Dendritic Cells Constitute the Major Infected Cell Type during the Chronic Leishmania major Infection Phase of C57BL/6 Resistant Mice

Carl De Trez,
Stefan Magez,
Shizuo Akira,
Bernhard Ryffel,
Yves Carlier,
Eric Muraille

Published: June 26, 2009
https://doi.org/10.1371/journal.ppat.1000494

About the Authors

Carl De Trez

Affiliation Laboratoire de Parasitologie, Faculté de Médecine, Université Libre de Bruxelles, Brussels, Belgium

Stefan Magez

Affiliation Department of Molecular and Cellular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Brussels, Belgium

Shizuo Akira

Affiliation Department of Host Defense, Research Institute for Microbial Diseases, Osaka University Yamadaoka, Suita City, Osaka, Japan

Bernhard Ryffel

Affiliation University of Orleans, Transgenose Institute, CNRS, UMR 6218, Orleans, France

Yves Carlier

Affiliation Laboratoire de Parasitologie, Faculté de Médecine, Université Libre de Bruxelles, Brussels, Belgium

Eric Muraille

* E-mail: emuraille@hotmail.com

Affiliation Laboratoire de Parasitologie, Faculté de Médecine, Université Libre de Bruxelles, Brussels, Belgium

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CDT EM. Performed the experiments: CDT EM. Analyzed the data: CDT EM. Contributed reagents/materials/analysis tools: SM SA BR YC EM. Wrote the paper: CDT EM.

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Inflammation
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Lymph nodes
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Parasitic diseases
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Mouse models
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Leishmania
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Protozoan infections
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Flow cytometry
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Promastigotes
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