A Lipid Receptor Sorts Polyomavirus from the Endolysosome to the Endoplasmic Reticulum to Cause Infection

Mengding Qian; Dawen Cai; Kristen J. Verhey; Billy Tsai

doi:10.1371/journal.ppat.1000465

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Open Access

Peer-reviewed

Research Article

A Lipid Receptor Sorts Polyomavirus from the Endolysosome to the Endoplasmic Reticulum to Cause Infection

Mengding Qian ,

Contributed equally to this work with: Mengding Qian, Dawen Cai

Affiliation Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
⨯
Dawen Cai ,

Contributed equally to this work with: Mengding Qian, Dawen Cai

Affiliation Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Kristen J. Verhey,

Affiliation Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
⨯
Billy Tsai

* E-mail: btsai@umich.edu

Affiliation Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
⨯

A Lipid Receptor Sorts Polyomavirus from the Endolysosome to the Endoplasmic Reticulum to Cause Infection

Mengding Qian,
Dawen Cai,
Kristen J. Verhey,
Billy Tsai

Published: June 5, 2009
https://doi.org/10.1371/journal.ppat.1000465

About the Authors

Mengding Qian

Contributed equally to this work with: Mengding Qian, Dawen Cai

Affiliation Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Dawen Cai

Contributed equally to this work with: Mengding Qian, Dawen Cai

Affiliation Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

Kristen J. Verhey

Affiliation Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Billy Tsai

* E-mail: btsai@umich.edu

Affiliation Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MQ DC BT. Performed the experiments: MQ DC BT. Analyzed the data: MQ DC KJV BT. Contributed reagents/materials/analysis tools: MQ BT. Wrote the paper: MQ DC KJV BT.

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Endosomes
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Sphingolipids
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Endoplasmic reticulum
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Vesicles
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Cell membranes
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NIH 3T3 cells
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Lysosomes
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Antibodies
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