About the Authors

Rik L de Swart

To whom correspondence should be addressed. E-mail: r.deswart@erasmusmc.nl

Affiliation Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

Martin Ludlow

Contributed equally to this work with: Martin Ludlow, Lot de Witte

Affiliation School of Biomedical Sciences, Queen's University of Belfast, United Kingdom

Lot de Witte

Contributed equally to this work with: Martin Ludlow, Lot de Witte

Affiliation Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands

Yusuke Yanagi

Affiliation Department of Virology, Kyushu University, Fukuoka, Japan

Geert van Amerongen

Affiliation Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

Stephen McQuaid

Affiliation School of Biomedical Sciences, Queen's University of Belfast, United Kingdom

Selma Yüksel

Affiliation Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

Teunis B. H Geijtenbeek

Affiliation Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands

W. Paul Duprex

Affiliation School of Biomedical Sciences, Queen's University of Belfast, United Kingdom

Albert D. M. E Osterhaus

Affiliation Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ML and LdW contributed equally to this study. RLdS, TBHG, WPD, and ADMEO designed and planned the study. RLdS coordinated the study and wrote the manuscript, to which all authors provided feedback. All authors approved the final version of the manuscript. RLdS and GvA undertook the infection experiments and obtained study samples and macroscopic images. YY provided the plasmid from which the recombinant virus was rescued. RLdS and SY performed the virological and serological experiments and the FACS assays. RLdS prepared Figures 1–4, Tables S1–S3, and Figures S1 and S2. LdW performed virus detection assays in samples from skin and mouth and prepared Figures 5 and S3. ML and SM performed virus detection assays in other organs and prepared Figures 6 and S4.