About the Authors

Keith E Garrison, Lishomwa C Ndhlovu, Joan M Chapman, Ann L Erickson, Douglas F Nixon
Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America

R. Brad Jones, Naveed Anwar, Mario A Ostrowski
Department of Immunology, University of Toronto, Toronto, Ontario, Canada

Duncan A Meiklejohn, Ashish Agrawal
Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California, United States of America

Gerald Spotts, Frederick M Hecht
Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

Seth Rakoff-Nahoum
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America

Jack Lenz
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York, United States of America

Mario A Ostrowski
St. Michael's Hospital, Toronto, Ontario, Canada

Corresponding Authors

Competing Interests

KEG, RBJ, DAM, AA, FMH, SRN, JL, MAO, and DFN are named as inventors on a patent application, based on this work, which was filed by their respective institutions.

Author Contributions

KEG, RBJ, MAO, and DFN composed the manuscript and planned the experimentation for this work. RBJ designed, validated, and performed the quantitative PCR experiments with the assistance of NA. KEG, NA, DAM, and RBJ, JMC, and DFN performed the ELISPOT analysis of T cell responses. ALE performed the 51Cr-release assays. AA performed the initial database searches to identify peptide sequences, with KEG, AA, FMH, and DFN developing the selection process for the peptides. KEG and LCN performed the multicolor flow cytometry experiments. FMH directs the OPTIONS cohort, with GS as data manager, which provided samples for the study. SRN and JL were important early contributors to the initial selection of HERV insertions on which to focus further experimentation. MAO and DFN are equal last authors.