About the Authors

Diana L Martin

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

D. Brent Weatherly

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

Susana A Laucella

Affiliation Instituto Nacional de Parasiologia Dr. Mario Fatala Chaben/Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS/Malbran), Buenos Aires, Argentina

Melissa A Cabinian

Affiliation Department of Microbiology, University of Georgia, Athens, Georgia, United States of America

Matthew T Crim

Affiliation Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

Susan Sullivan

¤ Current address: Department of Biological Sciences, Louisiana State University at Alexandria, Alexandria, Louisiana, United States of America

Affiliation Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

Mark Heiges

Affiliation Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

Sarah H Craven

Affiliation Department of Microbiology, University of Georgia, Athens, Georgia, United States of America

Charles S Rosenberg

Affiliations Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America , Department of Microbiology, University of Georgia, Athens, Georgia, United States of America

Matthew H Collins

Affiliation Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

Alessandro Sette

Affiliation La Jolla Institute for Allergy and Immunology, San Diego, California, United States of America

Miriam Postan

Affiliation Instituto Nacional de Parasiologia Dr. Mario Fatala Chaben/Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán” (ANLIS/Malbran), Buenos Aires, Argentina

Rick L Tarleton

To whom correspondence should be addressed. E-mail: tarleton@cb.uga.edu

Affiliations Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America , Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

DLM conducted the murine experiments except where noted. DBW performed the bioinformatics for all studies. SAL and MP performed the human studies and studies on the HLA-A2 transgenic mice (Figure S2). SS and MH carried out the initial identification of ts epitopes (Table S1). MAC, SHC, CSR, and MHC provided experimental data for Tables S1 and S2. MTC did initial in vivo cytotoxic T lymphocyte studies of ts epitopes (Figure 1B). AS determined the HLA-A2–binding affinities of peptides and predicted the H-2Kb–binding affinities of peptides. RLT provided the financial and intellectual support for all studies.