Increased Fidelity Reduces Poliovirus Fitness and Virulence under Selective Pressure in Mice

Open Access

Peer-reviewed

Research Article

Julie K. Pfeiffer,

Affiliation Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Karla Kirkegaard

*To whom correspondence should be addressed. E-mail: karlak@stanford.edu

Affiliation Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
⨯

About the Authors

Julie K. Pfeiffer

Affiliation Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America

Karla Kirkegaard

*To whom correspondence should be addressed. E-mail: karlak@stanford.edu

Affiliation Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America

The authors have declared that no competing interests exist.

JKP and KK conceived and designed the experiments. JKP performed the experiments. JKP and KK analyzed the data, and wrote the paper.

Poliovirus
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Microbial mutation
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Point mutation
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HeLa cells
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Viral replication
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RNA viruses
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Polymerases
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Viral pathogens
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