Tumor Progression Locus 2 Promotes Induction of IFNλ, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus

Teneema Kuriakose; Ralph A. Tripp; Wendy T. Watford

doi:10.1371/journal.ppat.1005038

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Open Access

Peer-reviewed

Research Article

Tumor Progression Locus 2 Promotes Induction of IFNλ, Interferon Stimulated Genes and Antigen-Specific CD8⁺ T Cell Responses and Protects against Influenza Virus

Teneema Kuriakose,

Affiliation Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America
⨯
Ralph A. Tripp,

Affiliation Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America
⨯
Wendy T. Watford

* E-mail: watfordw@uga.edu

Affiliation Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America
⨯

Tumor Progression Locus 2 Promotes Induction of IFNλ, Interferon Stimulated Genes and Antigen-Specific CD8⁺ T Cell Responses and Protects against Influenza Virus

Teneema Kuriakose,
Ralph A. Tripp,
Wendy T. Watford

Published: August 4, 2015
https://doi.org/10.1371/journal.ppat.1005038

About the Authors

Teneema Kuriakose

Affiliation Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America

Ralph A. Tripp

Affiliation Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America

Wendy T. Watford

* E-mail: watfordw@uga.edu

Affiliation Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TK RAT WTW. Performed the experiments: TK WTW. Analyzed the data: TK WTW. Contributed reagents/materials/analysis tools: RAT WTW. Wrote the paper: TK RAT WTW.

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Influenza viruses
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Viral replication
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Interferons
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Cytotoxic T cells
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T cells
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Respiratory infections
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ERK signaling cascade
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Immune receptor signaling
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