About the Authors

Kristen M. Varney

Contributed equally to this work with: Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu

Affiliation NMR Facility, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America

Alexandre M. J. J. Bonvin

Contributed equally to this work with: Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu

Affiliation Utrecht University, Bijvoet Center for Biomolecular Research, Faculty of Science-Chemistry, Utrecht, The Netherlands

Marzena Pazgier

Contributed equally to this work with: Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu

Affiliation Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America

Jakob Malin

Contributed equally to this work with: Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu

Affiliation Maastricht University Medical Center, Maastricht, The Netherlands

Wenbo Yu

Contributed equally to this work with: Kristen M. Varney, Alexandre M. J. J. Bonvin, Marzena Pazgier, Jakob Malin, Wenbo Yu

Affiliation Department of Pharmaceutical Sciences and Computer-Aided Drug Design Center, University of Maryland, School of Pharmacy, Baltimore, Maryland, United States of America

Eugene Ateh

Affiliation Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America

Taiji Oashi

Affiliation Department of Pharmaceutical Sciences and Computer-Aided Drug Design Center, University of Maryland, School of Pharmacy, Baltimore, Maryland, United States of America

Wuyuan Lu

Affiliation Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America

Jing Huang

Affiliation Department of Pharmaceutical Sciences and Computer-Aided Drug Design Center, University of Maryland, School of Pharmacy, Baltimore, Maryland, United States of America

Marlies Diepeveen-de Buin

Affiliation Utrecht University, Bijvoet Center for Biomolecular Research, Faculty of Science-Chemistry, Utrecht, The Netherlands

Joseph Bryant

Affiliation Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America

Eefjan Breukink

Affiliation Utrecht University, Bijvoet Center for Biomolecular Research, Faculty of Science-Chemistry, Utrecht, The Netherlands

Alexander D. MacKerell Jr

Affiliation Department of Pharmaceutical Sciences and Computer-Aided Drug Design Center, University of Maryland, School of Pharmacy, Baltimore, Maryland, United States of America

Erik P. H. de Leeuw

edeleeuw@som.umaryland.edu

Affiliation Institute of Human Virology & Department of Biochemistry and Molecular Biology of the University of Maryland Baltimore School of Medicine, Baltimore, Maryland, United States of America

Competing Interests

I have read the journal's policy and have the following conflicts: US patent application # 61/656,039 has been filed (ADM and EPHdL, Inventors). This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AMJJB ADM EPHdL. Performed the experiments: KMV WY AMJJB MP JM EA TO JH MDdB EPHdL. Analyzed the data: KMV AMJJB JB EB ADM EPHdL. Contributed reagents/materials/analysis tools: WL. Wrote the paper: EPHdL.