Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression

Anton Soucy-Faulkner; Espérance Mukawera; Karin Fink; Alexis Martel; Loubna Jouan; Yves Nzengue; Daniel Lamarre; Christine Vande Velde; Nathalie Grandvaux

doi:10.1371/journal.ppat.1000930

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Peer-reviewed

Research Article

Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression

Anton Soucy-Faulkner ,

Contributed equally to this work with: Anton Soucy-Faulkner, Espérance Mukawera

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Biochemistry, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
⨯
Espérance Mukawera ,

Contributed equally to this work with: Anton Soucy-Faulkner, Espérance Mukawera

Affiliation CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada
⨯
Karin Fink,

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Biochemistry, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
⨯
Alexis Martel,

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Biochemistry, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
⨯
Loubna Jouan,

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
⨯
Yves Nzengue,

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Biochemistry, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
⨯
Daniel Lamarre,

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
⨯
Christine Vande Velde,

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
⨯
Nathalie Grandvaux

* E-mail: nathalie.grandvaux@umontreal.ca

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Biochemistry, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada
⨯

Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression

Anton Soucy-Faulkner,
Espérance Mukawera,
Karin Fink,
Alexis Martel,
Loubna Jouan,
Yves Nzengue,
Daniel Lamarre,
Christine Vande Velde,
Nathalie Grandvaux

Published: June 3, 2010
https://doi.org/10.1371/journal.ppat.1000930

About the Authors

Anton Soucy-Faulkner

Contributed equally to this work with: Anton Soucy-Faulkner, Espérance Mukawera

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Biochemistry, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada

Espérance Mukawera

Contributed equally to this work with: Anton Soucy-Faulkner, Espérance Mukawera

Affiliation CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada

Karin Fink

Alexis Martel

Loubna Jouan

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada

Yves Nzengue

Daniel Lamarre

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada

Christine Vande Velde

Affiliations CRCHUM - Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada, Department of Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada

Nathalie Grandvaux

* E-mail: nathalie.grandvaux@umontreal.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ASF NG. Performed the experiments: ASF EM KF AM LJ YN CVV NG. Analyzed the data: ASF KF CVV NG. Contributed reagents/materials/analysis tools: DL. Wrote the paper: ASF NG. Supervised Loubna Jouan: DL.

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Transfection
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RNA interference
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Phosphorylation
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Immunoblotting
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Transcription factors
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Mitochondria
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Redox signaling
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Gene regulation
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