A Single CD8+ T Cell Epitope Sets the Long-Term Latent Load of a Murid Herpesvirus

Sofia Marques; Marta Alenquer; Philip G. Stevenson; J. Pedro Simas

doi:10.1371/journal.ppat.1000177

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Peer-reviewed

Research Article

A Single CD8⁺ T Cell Epitope Sets the Long-Term Latent Load of a Murid Herpesvirus

Sofia Marques,

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Marta Alenquer,

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Philip G. Stevenson,

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
⨯
J. Pedro Simas

* E-mail: psimas@fm.ul.pt

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯

A Single CD8⁺ T Cell Epitope Sets the Long-Term Latent Load of a Murid Herpesvirus

Sofia Marques,
Marta Alenquer,
Philip G. Stevenson,
J. Pedro Simas

Published: October 17, 2008
https://doi.org/10.1371/journal.ppat.1000177

About the Authors

Sofia Marques

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Marta Alenquer

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Philip G. Stevenson

Affiliation Division of Virology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom

J. Pedro Simas

* E-mail: psimas@fm.ul.pt

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SM PGS JPS. Performed the experiments: SM MA. Analyzed the data: SM JPS. Contributed reagents/materials/analysis tools: SM. Wrote the paper: SM PGS JPS.

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T cells
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Viral persistence and latency
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Cytotoxic T cells
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B cells
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Mammalian genomics
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Spleen
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Viral load
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Polymerase chain reaction
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