DC-SIGN on B Lymphocytes Is Required For Transmission of HIV-1 to T Lymphocytes

Giovanna Rappocciolo; Paolo Piazza; Craig L Fuller; Todd A Reinhart; Simon C Watkins; David T Rowe; Mariel Jais; Phalguni Gupta; Charles R Rinaldo Jr.

doi:10.1371/journal.ppat.0020070

Loading metrics

Open Access

Peer-reviewed

Research Article

DC-SIGN on B Lymphocytes Is Required For Transmission of HIV-1 to T Lymphocytes

Giovanna Rappocciolo ,

*To whom correspondence should be addressed. E-mail: giovanna@pitt.edu

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Paolo Piazza,

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Craig L Fuller,

¤ Current address: School of Health Sciences, Eastern Michigan University, Ypsilanti, Michigan, United States of America

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Todd A Reinhart,

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Simon C Watkins,

Affiliation Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
David T Rowe,

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Mariel Jais,

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Phalguni Gupta,

Affiliations Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America , Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Charles R Rinaldo Jr.

Affiliations Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America , Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

DC-SIGN on B Lymphocytes Is Required For Transmission of HIV-1 to T Lymphocytes

Giovanna Rappocciolo,
Paolo Piazza,
Craig L Fuller,
Todd A Reinhart,
Simon C Watkins,
David T Rowe,
Mariel Jais,
Phalguni Gupta,
Charles R Rinaldo Jr.

Published: July 14, 2006
https://doi.org/10.1371/journal.ppat.0020070

About the Authors

Giovanna Rappocciolo

*To whom correspondence should be addressed. E-mail: giovanna@pitt.edu

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Paolo Piazza

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Craig L Fuller

¤ Current address: School of Health Sciences, Eastern Michigan University, Ypsilanti, Michigan, United States of America

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Todd A Reinhart

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Simon C Watkins

Affiliation Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

David T Rowe

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Mariel Jais

Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Phalguni Gupta

Affiliations Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America , Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Charles R Rinaldo Jr.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GR and CRR conceived and designed the experiments. GR, PP, CLF, and MJ performed the experiments. TAR, SCW, DTR, and PG contributed reagents/materials/analysis tools. GR and CRR analyzed the data and wrote the paper.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.
HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
B cell receptors
Is the Subject Area "B cell receptors" applicable to this article?

Thanks for your feedback.
Tonsils
Is the Subject Area "Tonsils" applicable to this article?

Thanks for your feedback.
T cell receptors
Is the Subject Area "T cell receptors" applicable to this article?

Thanks for your feedback.