Site NT Site Mutation Amino acid Site aaMuatation AASiteChangedAA mutation_type motif Nb.of.hosts Host(Day) EpiScale Same Yard Yards Convergent 2 T2C M1T Met1Thr NA nonsyn 2 H24(94) L42(109) no H(1) L(1) T2C 7 A7G T3A Thr3Ala NA nonsyn 3 K22(92) L47(111) M29(98) yes M(1) L(1) K(1) A7G 10 A10G T4A Thr4Ala NA nonsyn 2 E13(90) M32(100) yes E(1) M(1) 14 T14C I5T Ile5Thr NA nonsyn 3 L40(107) E10(87) L44(109) yes E(1) L(2) T14C 23 T23C I8T Ile8Thr NA nonsyn 2 N37(104) J21(92) no J(1) N(1) 31 A31G T11A Thr11Ala NA nonsyn 3 N37(104) L42(111) J21(92) no L(1) J(1) N(1) A31G 42 C42T A14A Ala14Ala NA syn 2 L40(107) M29(98) yes M(1) L(1) 52 A52G N18D Asn18Asp NA nonsyn 2 E18(91) S41(107) yes E(1) S(1) A58G 58 A58G I20V Ile20Val NA nonsyn 2 V46(128) L42(109) yes V(1) L(1) T59C 59 T59C I20T Ile20Thr NA nonsyn 2 L42(109) N28(99) yes L(1) N(1) T63C 63 T63C S21S Ser21Ser NA syn 2 N37(104) L43(109) yes L(1) N(1) 67 A67G N23D Asn23Asp glyco_site1_affected nonsyn 4 O33(101) M32(100) B03(84) T48(112) yes O(1) T(1) B(1) M(1) C69T 69 C69T N23N Asn23Asn NA syn 2 S41(107) T48(112) yes T(1) S(1) A70G 70 A70G N24D Asn24Asp glyco_site2-nonaffected nonsyn 2 S41(107) C04(85) no C(1) S(1) 73 A73G T25A Thr25Ala glyco_site3_affected nonsyn 2 N37(104) C04(85) no C(1) N(1) 85 T85C C29R Cys29Arg NA nonsyn 4 D06(86) V46(128) H16(91) T48(112) no T(1) H(1) V(1) D(1) 87 T87C C29C Cys29Cys NA syn 2 K22(92) A01(72) yes A(1) K(1) 93 A93G G31G Gly31Gly NA syn 5 K22(92) H24(94) L42(111) C04(85) L43(109) no H(1) L(2) C(1) K(1) A93G 98 A98G H33R His33Arg NA nonsyn 2 V46(128) L42(111) no V(1) L(1) A98G 102 A102G A34A Ala34Ala NA syn 3 S41(107) L42(111) A01(72) no A(1) L(1) S(1) A102G 106 G106A A36T Ala36Thr NA nonsyn 2 S41(107) L42(111) no L(1) S(1) 115 A115G T39A Thr39Ala glyco_site3_affected nonsyn 2 E15(90) N37(104) no E(1) N(1) 119 T119C L40S Leu40Ser NA nonsyn 3 V46(128) E10(87) Q36(104) no E(1) V(1) Q(1) T119C 122 T122C V41A Val41Ala NA nonsyn 2 H24(94) E10(87) no E(1) H(1) 124 A124G K42E Lys42Glu NA nonsyn 2 E13(90) L25(100) no E(1) L(1) A124G 127 A127G T43A Thr43Ala NA nonsyn 2 Q36(104) P35(104) no Q(1) P(1) A127G 135 T135C S45S Ser45Ser NA syn 3 L42(111) R38(104) G08(87) no R(1) G(1) L(1) 137 A137G D46G Asp46Gly NA nonsyn 2 N28(99) E10(87) no E(1) N(1) 138 T138C D46D Asp46Asp NA syn 2 N28(99) T48(112) no T(1) N(1) 141 T141C D47D Asp47Asp NA syn 3 U49(118) W50(128) unknown(unknown) yes unknown(1) W(1) U(1) 152 T152C V51A Val51Ala NA nonsyn 4 O33(101) B02(84) M31(99) B03(84) no O(1) B(2) M(1) 153 G153A V51V Val51Val NA syn 2 E07(86) G08(87) yes E(1) G(1) 154 A154G T52A Thr52Ala NA nonsyn 3 E09(87) O33(101) L43(109) no O(1) E(1) L(1) A154G 156 A156G T52T Thr52Thr NA syn 2 L25(100) H24(94) no H(1) L(1) A156G 158 A158G N53S Asn53Ser glyco_site1_affected nonsyn 2 L25(100) L42(109) no yes L(2) 176 A176G Q59R Gln59Arg NA nonsyn 2 E09(87) N28(99) no E(1) N(1) 179 G179A S60N Ser60Asn NA nonsyn 2 L25(98) N37(104) no L(1) N(1) G179A 182 T182C I61T Ile61Thr NA nonsyn 2 N37(104) N28(99) yes yes N(2) 184 T184C S62P Ser62Pro antigenic_site_Ea nonsyn 2 L25(100) P35(104) yes L(1) P(1) T184C 188 T188C M63T Met63Thr antigenic_site_Ea nonsyn 2 E13(90) M29(98) yes E(1) M(1) 192 G192A G64G Gly64Gly NA syn 2 E09(87) unknown(unknown) yes unknown(1) E(1) 193 A193G K65E Lys65Glu NA nonsyn 2 E13(90) M31(99) no E(1) M(1) 198 A198G I66M Ile66Met NA nonsyn 2 L25(100) Q36(104) no Q(1) L(1) 203 A203G N68S Asn68Ser antigenic_site_Ca nonsyn 2 L25(100) I17(91) no I(1) L(1) A203G 211 T211C Y71H Tyr71His NA nonsyn 2 L25(100) J21(92) no L(1) J(1) T211C 225 T225C D75D Asp75Asp NA syn 2 L47(111) A01(72) no A(1) L(1) T225C 228 A228G G76G Gly76Gly NA syn 3 O33(101) N37(104) G08(87) yes O(1) G(1) N(1) A258G 230 G230A R77K Arg77Lys NA nonsyn 15 "E09(87) L39(105) L40(107) E18(91) L25(100,98) L27(104) S41(107) L42(109,111) L47(111) L30(unknown) N34(73) L43(109) Q36(104) L44(109) F11(87) " yes E(2) F(1) Q(1) L(9) N(1) S(1) 232 A232G N78D Asn78Asp glyco_site1_affected nonsyn 2 unknown(unknown) N34(73) no unknown(1) N(1) 234 T234A N78K Asn78Lys glycosylation_site nonsyn 3 L25(100) S41(107) L42(111) yes L(2) S(1) 240 A240G T80T Thr80Thr NA syn 2 H23(94) E10(87) yes E(1) H(1) 248 A248G D83G Asp83Gly NA nonsyn 3 E09(87) N37(104) N28(99) yes E(1) N(2) 255 G255A M85I Met85Ile NA nonsyn 2 N37(104) M32(100) no M(1) N(1) 257 T257C L86P Leu86Pro NA nonsyn 3 B02(84) M32(100) A01(72) no A(1) B(1) M(1) 258 A258G L86L Leu86Leu NA syn 2 L42(111) N28(99) yes L(1) N(1) 262 G262A D88N Asp88Asn NA nonsyn 2 D05(86) L25(98) yes D(1) L(1) G262A 263 A263G D88G Asp88Gly NA nonsyn 3 E09(87) K22(92) E10(87) no E(2) K(1) 269 A269G H90R His90Arg NA nonsyn 2 C04(85) P35(104) no P(1) C(1) 270 C270T H90H His90His NA syn 2 H16(91) T48(112) yes T(1) H(1) 273 T273C C91C Cys91Cys NA syn 2 S41(107) E10(87) yes E(1) S(1) T273C 275 A275G D92G Asp92Gly NA nonsyn 3 L39(105) K22(92) M29(98) no M(1) L(1) K(1) A275G 278 T278C V93A Val93Ala NA nonsyn 5 O33(101) L39(105) L40(107) E10(87) A01(72) yes O(1) E(1) A(1) L(2) T278C 280 T280C F94L Phe94Leu NA nonsyn 2 unknown(unknown) N28(99) no unknown(1) N(1) 284 A284G Q95R Gln95Arg NA nonsyn 3 L25(98) H24(94) C04(85) yes H(1) L(1) C(1) A284G 287 A287G Y96C Tyr96Cys NA nonsyn 2 E18(91) N34(73) no E(1) N(1) A287G 299 A299G D100G Asp100Gly NA nonsyn 5 O33(101) N45(112) M32(100) L42(109) C04(85) no O(1) L(1) M(1) C(1) N(1) A299G 302 T302C L101P Leu101Pro NA nonsyn 2 N37(104) M29(98) no M(1) N(1) 320 G320A S107N Ser107Asn NA nonsyn 2 unknown(unknown) H16(91) yes unknown(1) H(1) 324 T324C A108A Ala108Ala NA syn 3 H23(94) unknown(unknown) A01(72) yes unknown(1) A(1) H(1) 328 A328G S110G Ser110Gly NA nonsyn 2 L40(107) S41(107) no L(1) S(1) 336 C336T C112C Cys112Cys NA syn 3 D20(92) M32(100) L42(111) yes D(1) L(1) M(1) C336T 338 A338G Y113C Tyr113Cys NA nonsyn 2 L42(111) L30(unknown) no yes L(2) A338G 344 A344G Y115C Tyr115Cys NA nonsyn 3 B02(84) M32(100) E10(87) no E(1) B(1) M(1) 345 T345C Y115Y Tyr115Tyr NA syn 2 E18(91) M29(98) yes E(1) M(1) T345C 347 A347G D116G Asp116Gly NA nonsyn 4 E13(90) K22(92) L42(111) C04(85) yes E(1) L(1) C(1) K(1) A347G 357 C357T D119D Asp119Asp NA syn 2 L25(100) H16(91) yes H(1) L(1) C357T 358 T358C Y120H Tyr120His NA nonsyn 2 L25(100) W50(128) yes W(1) L(1) T358C 360 T360C Y120Y Tyr120Tyr NA syn 2 U49(118) G08(87) no G(1) U(1) 364 T364C S122P Ser122Pro antigenic_site_Eb nonsyn 3 B02(84) L25(100) N37(104) yes B(1) L(1) N(1) T364C 365 C365T S122L Ser122Leu antigenic_site_Eb nonsyn 2 E13(90) B02(84) yes E(1) B(1) 366 G366A S122S Ser122Ser NA syn 3 W50(128) S41(107) E10(87) yes E(1) W(1) S(1) G366A 380 T380C V127A Val127Ala NA nonsyn 2 N28(99) E10(87) no E(1) N(1) 394 A394G T132A Thr132Ala NA nonsyn 2 L25(98) K22(92) no L(1) K(1) A394G 398 T398C L133S Leu133Ser NA nonsyn 2 E09(87) W50(128) no E(1) W(1) 409 G409A A137T Ala137Thr NA nonsyn 2 D20(92) L42(111) no D(1) L(1) 413 A413G E138G Glu138Gly NA nonsyn 3 E09(87) B03(84) R38(104) no R(1) E(1) B(1) 421 A421G T141A Thr141Ala NA nonsyn 3 E13(90) E18(91) I17(91) yes E(2) I(1) A421G 423 A423G T141T Thr141Thr NA syn 2 K22(92) N28(99) no N(1) K(1) 427 A427G T143A Thr143Ala NA nonsyn 3 L42(111) M29(98) I17(91) no I(1) M(1) L(1) A427G 432 T432C G144G Gly144Gly NA syn 3 L42(111) C04(85) G08(87) no G(1) L(1) C(1) T432C 434 T434C V145A Val145Ala NA nonsyn 5 N45(112) L27(100) unknown(unknown) C04(85) Q36(104) no unknown(1) Q(1) L(1) C(1) N(1) T434C 435 C435T V145V Val145Val NA syn 2 M32(100) unknown(unknown) no unknown(1) M(1) 436 A436G T146A Thr146Ala NA nonsyn 2 E09(87) L25(100) no E(1) L(1) A436G 438 T438C T146T Thr146Thr NA syn 2 L40(107) E15(90) yes E(1) L(1) T438C 456 A456G G152G Gly152Gly NA syn 2 B02(84) H24(94) yes H(1) B(1) 460 T460C C154R Cys154Arg antigenic_site_A nonsyn 2 E10(87) I17(91) no E(1) I(1) 462 C462T C154C Cys154Cys NA syn 2 E13(90) L30(unknown) no E(1) L(1) C462T 464 A464G K155R Lys155Arg antigenic_site_A nonsyn 2 O33(101) N28(99) yes O(1) N(1) 466 A466G R156G Arg156Gly antigenic_site_A nonsyn 5 E09(87) H23(94) L47(111) R38(104) I17(91) no R(1) E(1) H(1) I(1) L(1) A466G 483 T483C S161S Ser161Ser NA syn 2 N37(104) E10(87) no E(1) N(1) 495 A495G R165R Arg165Arg NA syn 2 E14(90) K22(92) no E(1) K(1) 497 T497C L166P Leu166Pro NA nonsyn 3 E09(87) E18(91) E10(87) no yes E(3) T497C 514 T514C S172P Ser172Pro NA nonsyn 2 E09(87) Q36(104) no E(1) Q(1) T514C 525 T525C S175S Ser175Ser NA syn 2 E09(87) L25(98) yes E(1) L(1) T525C 532 A532G T178A Thr178Ala NA nonsyn 3 L27(100) A01(72) I17(91) no A(1) I(1) L(1) 534 A534G T178T Thr178Thr NA syn 2 L25(100) T48(112) yes T(1) L(1) A534G 535 T535C L179L Leu179Leu NA syn 2 G08(87) H16(91) yes H(1) G(1) 536 T536C L179S Leu179Ser NA nonsyn 2 O33(101) N37(104) no O(1) N(1) 542 T542C V181A Val181Ala glyco_site2-nonaffected nonsyn 2 L25(100) D06(86) no D(1) L(1) T542C 544 A544G T182A Thr182Ala glyco_site3_affected nonsyn 3 L25(100) K22(92) L42(109) no L(2) K(1) A544G 552 T552C P184P Pro184Pro NA syn 2 E13(90) O33(101) yes O(1) E(1) 554 A554G N185S Asn185Ser NA nonsyn 3 H24(94) L42(111) H16(91) no H(2) L(1) A554G 577 T577C Y193H Tyr193His NA nonsyn 2 O33(101) V46(128) no O(1) V(1) 585 G585A W195* Trp195* NA nonsyn 2 L25(100) M32(100) no M(1) L(1) G585A 590 T590C I197T Ile197Thr NA nonsyn 4 L25(100) H24(94) L42(109) H16(91) yes H(2) L(2) T590C 593 A593G H198R His198Arg NA nonsyn 2 L39(105) T48(112) no T(1) L(1) A593G 594 T594C H198H His198His NA syn 2 N28(99) Q36(104) yes Q(1) N(1) T594C 596 A596G H199R His199Arg NA nonsyn 3 C04(85) R38(104) I17(91) no R(1) I(1) C(1) 598 C598T P200S Pro200Ser NA nonsyn 2 N28(99) M29(98) no M(1) N(1) 599 C599T P200L Pro200Leu NA nonsyn 2 L27(100) E10(87) no E(1) L(1) 601 A601G S201G Ser201Gly NA nonsyn 2 E09(87) unknown(unknown) no unknown(1) E(1) 609 T609C N203N Asn203Asn NA syn 2 S41(107) H24(94) yes H(1) S(1) T609C 612 A612G Q204Q Gln204Gln NA syn 5 E15(90) V46(128) D20(92) M32(100) C04(85) yes E(1) D(1) V(1) M(1) C(1) 614 A614G E205G Glu205Gly antigenic_site_B nonsyn 3 N37(104) G08(87) T48(112) no T(1) G(1) N(1) 617 A617G Q206R Gln206Arg antigenic_site_B nonsyn 3 V46(128) R38(104) E10(87) no R(1) E(1) V(1) 619 A619G T207A Thr207Ala antigenic_site_B nonsyn 2 W50(128) R38(104) no R(1) W(1) 626 T626C L209S Leu209Ser antigenic_site_B nonsyn 2 H23(94) L25(98) no H(1) L(1) T626C 642 A642G S214S Ser214Ser NA syn 3 V46(128) E07(86) Q36(104) no E(1) V(1) Q(1) A642G 658 T658C S220P Ser220Pro hum_antigenic_D nonsyn 2 N37(104) S41(107) yes S(1) N(1) T658C 670 A670G S224G Ser224Gly antigenic_site_Db nonsyn 2 H23(94) K22(92) no H(1) K(1) 672 T672C S224S Ser224Ser NA syn 3 L42(109) T48(112) P35(104) yes T(1) L(1) P(1) T672C 675 A675G Q225Q Gln225Gln NA syn 2 U49(118) E10(87) no E(1) U(1) 679 A679G T227A Thr227Ala antigenic_site_Db nonsyn 4 N45(112) M31(99) C04(85) Q36(104) no Q(1) M(1) C(1) N(1) A679G 690 T690C P230P Pro230Pro NA syn 2 E09(87) N28(99) yes E(1) N(1) T690C 697 G697A G233R Gly233Arg NA nonsyn 2 S41(107) H24(94) yes H(1) S(1) G697A 705 A705G R235R Arg235Arg NA syn 3 L26(99) L42(111) T48(112) yes T(1) L(2) A705G 711 G711A W237* Trp237* NA nonsyn 2 A01(72) M29(98) no A(1) M(1) 715 A715G R239G Arg239Gly NA nonsyn 2 L40(107) A01(72) no A(1) L(1) A715G 720 T720C G240G Gly240Gly NA syn 3 E13(90) O33(101) N34(73) no O(1) E(1) N(1) T720C 729 C729T G243G Gly243Gly NA syn 2 O33(101) E18(91) yes O(1) E(1) C729T 730 A730G R244G Arg244Gly NA nonsyn 3 N37(104) C04(85) A01(72) no A(1) C(1) N(1) 738 C738T S246S Ser246Ser NA syn 2 S41(107) L43(109) yes L(1) S(1) 741 A741G I247M Ile247Met NA nonsyn 2 C04(85) N28(99) no N(1) C(1) 745 T745C W249R Trp249Arg NA nonsyn 2 D05(86) H24(94) yes H(1) D(1) 748 A748G T250A Thr250Ala NA nonsyn 2 B02(84) H16(91) no H(1) B(1) 754 G754A V252I Val252Ile NA nonsyn 2 C04(85) L43(109) no L(1) C(1) G754A 759 A759C K253N Lys253Asn NA nonsyn 2 L25(100) K22(92) no L(1) K(1) A759C 765 A765G G255G Gly255Gly NA syn 3 C04(85) N28(99) N34(73) yes N(2) C(1) 770 T770C I257T Ile257Thr antigenic_site_Dc nonsyn 2 M31(99) W50(128) yes W(1) M(1) 784 A784G S262G Ser262Gly NA nonsyn 2 M32(100) C04(85) yes M(1) C(1) 788 A788G N263S Asn263Ser NA nonsyn 3 H24(94) R38(104) E10(87) no R(1) E(1) H(1) 793 A793G N265D Asn265Asp NA nonsyn 5 E13(90) D05(86) W50(128) V46(128) T48(112) no E(1) T(1) V(1) W(1) D(1) 798 A798G L266L Leu266Leu NA syn 2 E13(90) L25(100) yes E(1) L(1) A798G 802 G802A A268T Ala268Thr NA nonsyn 2 H24(94) H16(91) yes yes H(2) 816 T816C Y272Y Tyr272Tyr NA syn 3 N45(112) V46(128) H24(94) yes H(1) V(1) N(1) 821 A821G K274R Lys274Arg NA nonsyn 2 K22(92) M32(100) yes M(1) K(1) 829 A829G T277A Thr277Ala NA nonsyn 2 L25(100) R38(104) yes R(1) L(1) A829G 835 A835G K279E Lys279Glu NA nonsyn 2 E19(91) E07(86) yes yes E(2) 836 A836G K279R Lys279Arg NA nonsyn 4 E13(90) M32(100) N28(99) E10(87) yes E(2) M(1) N(1) 841 T841C S281P Ser281Pro NA nonsyn 4 O33(101) L27(104) M32(100) N34(73) no O(1) M(1) L(1) N(1) T841C 852 A852G R284R Arg284Arg NA syn 2 O33(101) S41(107) yes O(1) S(1) A852G 855 A855G S285S Ser285Ser NA syn 3 E18(91) E14(90) I17(91) no E(2) I(1) A855G 857 A857G D286G Asp286Gly NA nonsyn 3 E09(87) L25(100) E10(87) no E(2) L(1) A857G 861 A861G V287V Val287Val NA syn 2 V46(128) S41(107) yes V(1) S(1) A861G 865 A865G I289V Ile289Val antigenic_site_Cb nonsyn 2 N37(104) J21(92) no J(1) N(1) 869 A869G D290G Asp290Gly antigenic_site_Cb nonsyn 2 E09(87) N45(112) yes E(1) N(1) 874 T874C C292R Cys292Arg antigenic_site_Cb nonsyn 2 H23(94) N37(104) no H(1) N(1) 876 T876C C292C Cys292Cys NA syn 4 L25(100) D06(86) K22(92) A01(72) no A(1) D(1) L(1) K(1) T876C 878 T878C V293A Val293Ala antigenic_site_Cb nonsyn 4 H23(94) V46(128) M32(100) C04(85) yes V(1) H(1) M(1) C(1) 880 T880C S294P Ser294Pro NA nonsyn 3 O33(101) E14(90) D20(92) no O(1) E(1) D(1) 890 T890C I297T Ile297Thr NA nonsyn 2 E15(90) E10(87) no yes E(2) 897 A897G P299P Pro299Pro NA syn 2 N37(104) T48(112) no T(1) N(1)