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As we only sequenced representative strains from group C/D, this Ks value may be an overestimate. The minimal Ks value, obtained under the hypothesis that sequence variation is null within these groups, would be 0.0123. The rate of synonymous substitution used above is based on the assumption that E. coli and Salmonella diverged 100 million years ago ADDIN EN.CITE Ochman198717700000000177Evolution in bacteria: evidence for a universal substitution rate in cellular genomesOchman, H.Wilson, A. C.Bacteria/*genetics*EvolutionFossils*Genes, Bacterial*Models, GeneticPhylogenyRNA, Ribosomal/geneticsResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Variation (Genetics)J Mol Evol1987261-274-86.[1]. If a higher rate of 0.03, estimated on the basis of E. coli laboratory mutation rate ADDIN EN.CITE Guttman199417200000000172789611913841994DecDetecting selective sweeps in naturally occurring Escherichia coli993-1003Department of Ecology and Evolution, State University of New York at Stony Brook 11794-5245.Guttman, D. S.Dykhuizen, D. E.GeneticsAllelesAnimalsAnimals, Wild/microbiologyBase SequenceCodon/geneticsDNA, Bacterial/geneticsDiarrhea/microbiologyEscherichia coli/*genetics/isolation & purificationFeces/microbiologyGenes, Structural, BacterialGlyceraldehyde-3-Phosphate Dehydrogenases/geneticsHumansMolecular Sequence DataPhylogeny*Polymorphism, GeneticResearch Support, U.S. Gov't, P.H.S.Salmonella/genetics*Selection (Genetics)Transaminases/geneticsUrine/microbiologyhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7896119[2] were used, the estimated age would be 0.41 million years for the tubercle bacilli species and 5,000 years for MTBC.
References
1. Ochman H, Wilson AC (1987) Evolution in bacteria: evidence for a universal substitution rate in cellular genomes. J Mol Evol 26: 74-86.
2. Guttman DS, Dykhuizen DE (1994) Detecting selective sweeps in naturally occurring Escherichia coli. Genetics 138: 993-1003
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