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Correction: Chemogenomic profiling in yeast reveals antifungal mode-of-action of polyene macrolactam auroramycin

  • Jin Huei Wong,
  • Mohammad Alfatah,
  • Kiat Whye Kong,
  • Shawn Hoon,
  • Wan Lin Yeo,
  • Kuan Chieh Ching,
  • Corinna Jie Hui Goh,
  • Mingzi M. Zhang,
  • Yee Hwee Lim,
  • Fong Tian Wong,
  • Prakash Arumugam
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Fig 10 is incorrect. Please see the correct Fig 10 here.

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Fig 10. Auroramycin causes hyperpolarization of yeast cells.

(A)diS-C3(3) fluorescence of wild type AH109 yeast cells suspensions at different concentrations of amiodarone. (B)diS-C3(3) fluorescence of wild type AH109 yeast cells suspensions at different concentrations of auroramycin. (C)diS-C3(3) fluorescence of wild type AH109 yeast cells suspensions at different concentrations of auroramycin-aglycon. (D)Ratio of fluorescence at 585 nm to 575 nm is plotted for various cultures treated in A-C. Error bars (n = 3 Mean ± S.D) are indicated in the plot. Asterisks indicate statistical significance of fluorescence ratios for amiodarone/auroramycin-treated cells versus DMSO-treated cells, as determined by the Student’s t test (**, 2-sided P < 0.01 and *, 2-sided P< 0.05). This experiment was performed twice and data from one experiment are shown here.

https://doi.org/10.1371/journal.pone.0221074.g001

Reference

  1. 1. Wong JH, Alfatah M, Kong KW, Hoon S, Yeo WL, Ching KC, et al. (2019) Chemogenomic profiling in yeast reveals antifungal mode-of-action of polyene macrolactam auroramycin. PLoS ONE 14(6): e0218189. https://doi.org/10.1371/journal.pone.0218189 pmid:31181115