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Open Access

Correction

Correction: Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis

  • Liat Izhak,
  • Gizi Wildbaum,
  • Steffen Jung,
  • Avi Stein,
  • Yuval Shaked,
  • Nathan Karin
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In Fig 2E, the wrong image appears in panel j and there are errors in the associated caption for panels g-i and j-l. Please see the corrected Fig 2 here.

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Fig 2. Bone marrow derived CD11b+CCR2+ cells are essential to support tumor development and angiogenesis.

(A) CD11b+ BMD cells from cx3cr1gfp CCR2+ CD45.1 mice were purified (left panel), analyzed fro the relative mummer of GFP+ cells (right panel) and transferred to CCR2−/− mice bearing CCR2+ tumor (B) shows imaging (IVIS) of a representative mouse as recorded using a GFP filter. (C) Imaging (IVIS) of the primary tumor on day 60, as recorded by the IVIS camera using–luciferin filter (recording luciferase activity of the cancer cells) as follows: CCR2+/+ C57BL/6 mice (WT) (a), CCR2−/− mice (b), CCR2−/− transplanted with BM of WT mice(c) and CCR2−/− transplanted with BM of CCR2−/−mice. All photos show a representative mouse per group (1 of 6 mice). (D) The computerized CCCD analysis of six mice per group. Results are shown as total flux (p/s ×104) ±SE. * Indicates p<0.001 (E) Histological, Immunohistochemical and immunofluorescence analyses of primary tumors from C57BL/6 WT mice, CCR2-/- (KO) mice, and CCR2-/- (KO) mice reconstituted with BM from WT mice. Panel a-c show H&E staining, d-f show anti -PCNA staining, g-i show anti VEGF, j-l show anti F4/80, m-o show anti CD31.

https://doi.org/10.1371/journal.pone.0195170.g001

Reference

  1. 1. Izhak L, Wildbaum G, Jung S, Stein A, Shaked Y, Karin N (2012) Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis. PLoS ONE 7(1): e28305. https://doi.org/10.1371/journal.pone.0028305 pmid:22279523

Citation: Izhak L, Wildbaum G, Jung S, Stein A, Shaked Y, Karin N (2018) Correction: Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis. PLoS ONE 13(4): e0195170. https://doi.org/10.1371/journal.pone.0195170

Published: April 12, 2018

Copyright: © 2018 Izhak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.