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Correction: Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2

  • Sei-Myoung Han,
  • Ye-Rin Coh,
  • Jin-Ok Ahn,
  • Goo Jang,
  • Soo Young Yum,
  • Sung-Keun Kang,
  • Hee-Woo Lee,
  • Hwa-Young Youn

Correction: Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2

  • Sei-Myoung Han, 
  • Ye-Rin Coh, 
  • Jin-Ok Ahn, 
  • Goo Jang, 
  • Soo Young Yum, 
  • Sung-Keun Kang, 
  • Hee-Woo Lee, 
  • Hwa-Young Youn
PLOS
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In the graph legend in Panel A of Fig 4, the color for RFP-ATMSCs is incorrect. Please see the corrected Fig 4 here.

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Fig 4. PCR analysis and immunofluorescence of liver markers after 28 days hepatogenic differentiation.

(A) The mRNA expression level of albumin (ALB) was strongly expressed in hepatogenically differentiated Oct4/Sox2-ATMSCs, whereas the expression level of α-fetoprotein (AFP) was lower than that of RFP-ATMSCs. The expression levels of transferrin were not significantly different in both cells. Undifferentiated ATMSCs and HepG2 were used as negative and positive controls, respectively. (B) Hepatocyte-like cells from RFP- and Oct4/Sox2-ATMSCs are confirmed by immunofluorescence staining for AFP and ALB. Nuclei were counterstained with Hoecst33342.

https://doi.org/10.1371/journal.pone.0183734.g001

Reference

  1. 1. Han S-M, Coh Y-R, Ahn J-O, Jang G, Yum SY, Kang S-K, et al. (2015) Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2. PLoS ONE 10(3): e0108874. https://doi.org/10.1371/journal.pone.0108874 pmid:25815812