(A-I) H&E stains of P0 urogenital sinuses. (A-C) Wild type histology shows high cell density in the mesenchyme surrounding the epithelial prostate buds (A, B), and urethral epithelium is composed of 4–6 cell layers with a smooth apical surface (C). (D-F) 12Gso/Tbx18LacZ compound heterozygotes present an intermediate phenotype in the UGS mesenchyme and the urethral epithelium. (G-I) Tbx18GFP/GFP mutants have very low mesenchymal cell density surrounding epithelial prostate buds. The urethral epithelium in these mutants is increased in thickness with larger cell volumes (compare arrows in C, F, and I). (J) Measurements of the epithelial thickness in the urethral epithelium. The epithelium on the dorsal side is significantly increased in thickness compared to wild type littermates.
Citation: The PLOS ONE Staff (2016) Correction: Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate. PLoS ONE11(6): e0157283. https://doi.org/10.1371/journal.pone.0157283
Published: June 3, 2016
Copyright: © 2016 The PLOS ONE Staff. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.