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Correction: An Endophytic Fungus, Talaromyces radicus, Isolated from Catharanthus roseus, Produces Vincristine and Vinblastine, Which Induce Apoptotic Cell Death

  • Padmini P. C. Palem,
  • Gini C. Kuriakose,
  • Chelliah Jayabaskaran

Correction: An Endophytic Fungus, Talaromyces radicus, Isolated from Catharanthus roseus, Produces Vincristine and Vinblastine, Which Induce Apoptotic Cell Death

  • Padmini P. C. Palem, 
  • Gini C. Kuriakose, 
  • Chelliah Jayabaskaran
PLOS
x

Figs 9, 10, 14, 15 and 16 are incorrect. Although the legends are accurate, the final formatted version are not present. The authors have provided the corrected figures here.

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Fig 9. LC-ESI-MS analysis of fungal VCR.

The mass spectrum of the fungal extract showed a (M+H+) peak at a molecular mass of 825.46, which was identical to that observed in the mass spectrum of the VCR standard.

https://doi.org/10.1371/journal.pone.0153111.g001

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Fig 10. LC-ESI-MS analysis of fungal VBL.

The mass spectrum of the fungal extract showed a (M+H+) peak at a molecular mass of 811.51, which was identical to that observed in the mass spectrum of the VBL standard.

https://doi.org/10.1371/journal.pone.0153111.g002

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Fig 14. Cell cycle distribution of HeLa cells treated with different concentrations of ‘fungal VCR’.

The sub-G0/G1, G1, S and G2/M phases are represented on the histogram as P5, P2, P4 and P3, respectively. A—control, B—fungal VCR (5 μg/ml), C—fungal VCR (10 μg/ml), D—fungal VCR (25 μg/ml) and E—percent apoptosis.

https://doi.org/10.1371/journal.pone.0153111.g003

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Fig 15. Induction of apoptosis in HeLa cells treated with different concentrations of ‘fungal VCR’, as determined by annexin V-FITC/PI dual staining.

A—untreated cells, B—cells + FITC, C—cells + PI, D—cells + FITC + PI, E—cells + FITC + PI + fungal VCR (5 μg/ml), F—cells + FITC + PI + fungal VCR (10 μg/ml), G—cells + FITC + PI +

https://doi.org/10.1371/journal.pone.0153111.g004

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Fig 16. Induction of mitochondrial membrane depolarization in HeLa cells treated with various concentrations of ‘fungal VCR’.

A—cells alone, B—cells + JC1 stain, C—cells + JC1 + 25 μM valinomycin (+ ve control), D—cells + JC1 + fungal VCR (5 μg/ml), E—cells + JC1 + fungal VCR (10 μg/ml), F—cells + JC1 + fungal VCR (25 μg/ml), G—standard VCR (2 nM) and H—percent loss of mitochondrial membrane depolarization.

https://doi.org/10.1371/journal.pone.0153111.g005

Reference

  1. 1. Palem PPC, Kuriakose GC, Jayabaskaran C (2015) An Endophytic Fungus, Talaromyces radicus, Isolated from Catharanthus roseus, Produces Vincristine and Vinblastine, Which Induce Apoptotic Cell Death. PLoS ONE 10(12): e0144476. pmid:26697875