Advertisement
Browse Subject Areas
?

Click through the PLOS taxonomy to find articles in your field.

For more information about PLOS Subject Areas, click here.

  • Loading metrics

Correction: Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor

  • Yayoi Yoshimura,
  • Akihiko Shiino,
  • Kazue Muraki,
  • Tadateru Fukami,
  • Shigeki Yamada,
  • Takeshi Satow,
  • Miyuki Fukuda,
  • Masaaki Saiki,
  • Masato Hojo,
  • Susumu Miyamoto,
  • Nobuyuki Onishi,
  • Hideyuki Saya,
  • Toshiro Inubushi,
  • Kazuhiko Nozaki,
  • Kenji Tanigaki

Correction: Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor

  • Yayoi Yoshimura, 
  • Akihiko Shiino, 
  • Kazue Muraki, 
  • Tadateru Fukami, 
  • Shigeki Yamada, 
  • Takeshi Satow, 
  • Miyuki Fukuda, 
  • Masaaki Saiki, 
  • Masato Hojo, 
  • Susumu Miyamoto
PLOS
x

Fig 7 is incorrect. Panel E was incorrectly labeled. The authors have provided a corrected version here.

thumbnail
Fig 7. Arsenic trioxide and 10058F4 combination treatment efficiently regressed established gliomas.

Experimental Design. GBM CSCs (RI03) CSCs (5 × 104 cells) were implanted intracranially into SCID mice. Two months after transplantation, tumor growth was monitored by MRI. Four days after tumor size measurement, Arsenic Trioxide (2.5 mg/kg), 10058F4 (25mg/Kg) or both were administered by i.p. injection once a day for 10 days. After 10-day drug treatments, tumor sizes were again measured. Representative images of T2-weighted MRI. The region of interest used to calculate the volume of brain tumor is indicated by a dashed line. (C)-(D) Representative photographs of hematoxylin / eosin staining of intracranial xenograft brain tumors. The boxed area in (C) is magnified in (D). Scale bar = 500μm. (E)-(F) Changes in tumor volume after 10-day treatment with arsenic trioxide and 10058F4 relative to the starting tumor volume for each individual mouse. Each bar represents a volume change of an individual mouse. The data in (E) is shown as the mean ± SD of the data for each individual mouse in (F).

https://doi.org/10.1371/journal.pone.0149826.g001

Reference

  1. 1. Yoshimura Y, Shiino A, Muraki K, Fukami T, Yamada S, Satow T, et al. (2015) Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor. PLoS ONE 10(6): e0128288. pmid:26038891