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Salt Reduction Interventions in Sub-Saharan Africa: A Systematic Review

Salt Reduction Interventions in Sub-Saharan Africa: A Systematic Review

  • Stella Kagwiria Muthuri, 
  • Samuel Oji Oti, 
  • Richard James Lilford, 
  • Oyinlola Oyebode
PLOS
x

Abstract

Background

Salt intake is associated with hypertension, the leading risk factor for cardiovascular disease. To promote population-level salt reduction, the World Health Organization recommends intervention around three core pillars: Reformulation of processed foods, consumer awareness, and environmental changes to increase availability and affordability of healthy food. This review investigates salt reduction interventions implemented and evaluated in sub-Saharan Africa (SSA).

Methods

MEDLINE and google scholar electronic databases were searched for articles meeting inclusion criteria. Studies that reported evaluation results of a salt intervention in SSA were identified. Titles and abstracts were screened, and articles selected for full-text review. Quality of included articles was assessed, and a narrative synthesis of the findings undertaken. PROSPERO registration number CRD42015019055.

Results

Seven studies representing four countries—South Africa, Nigeria, Ghana, and Tanzania—were included. Two examined product reformulation, one in hypertensive patients and the other in normotensive volunteers. Four examined consumer awareness interventions, including individualised counselling and advisory health sessions delivered to whole villages. One study used an environmental approach by offering discounts on healthy food purchases. All the interventions resulted in at least one significantly improved outcome measure including reduction in systolic blood pressure (BP), 24 hour urinary sodium excretion, or mean arterial BP.

Conclusions

More high quality studies on salt reduction interventions in the region are needed, particularly focused on consumer awareness and education in urban populations given the context of rapid urbanisation; and essentially, targeting product reformulation and environmental change, for greater promise for propagation across a vast, diverse continent.

Introduction

Cardiovascular disease (CVD) is the leading cause of death globally, with 80% of such deaths occurring in low- and middle-income countries (LMICs) [1]. Evidence shows that high sodium intake may increase blood pressure and consequently lead to hypertension, a leading risk factor for CVD [2, 3]. To promote healthy diets and physical activity, thereby curbing the rise in the prevalence of non-communicable diseases (NCDs), the World Health Assembly adopted the World Health Organisation (WHO) global strategy on diet, physical activity and health in 2004, and later endorsed the global NCD action plan 2008–2013. As part of the implementation of these strategies, WHO’s member states agreed to targets of a 30% and 25% reduction in mean population salt intake and relative reduction in raised blood pressure (systolic ≥140 mmHg and/or diastolic ≥90 mmHg) respectively, in order to meet a 25% reduction in global premature non-communicable disease (NCD) mortality by 2025 [4, 5].

Expert technical meetings were convened to discuss population-level salt reduction strategies, and the result was a recommendation that national programmes employ a multisectoral approach, and be built around three core pillars. The first pillar is product reformulation of industrially produced foods. To achieve realistic salt reduction targets, product reformulation ought to be approached in consultation with food producers and distributors, and include monitoring and evaluation, through implementation of mechanisms to track population-level sodium consumption and food sodium composition. Governments were called upon to play a leading role in monitoring and evaluation to this end, including allocation of appropriate resources such as trained staff and an appropriate budget, to facilitate these activities. Several methods were proposed to accomplish effective monitoring including 24 hour or spot urine collections, food diaries, food frequency questionnaires, and the development of food composition databases to allow for accurate assessment of the sodium content in foods. Analysing the sodium content of staple foods, including ethnic foods or foods from restaurants and street vendors, would also be helpful [47]. The second pillar is consumer awareness and education, which would best be achieved through campaigns targeting individuals or the catering sector, and focusing on knowledge, attitudes, and behaviours regarding salt intake through clear and simple messages. These messaged ought to be tested beforehand, and delivered by identified groups or individuals. It was further recommended that the messages encompass salt that is added during cooking, at the table, or from food consumed outside the home. The avenue of communication used should seek to target not only the general population, but particularly the most vulnerable groups. In addition, provision of information and training on how to read and interpret nutrition labels was also proposed as part of consumer awareness activities [46]. The third, environmental changes, through setting national targets and standards for food manufacturers and providers, thereby making healthy food choices easy and affordable at the population-level. Clear and comprehensive labelling was also included as a key aspect of environmental change. Experts identified the importance of synergising salt reduction interventions, through policy cohesion and collaboratively working towards policy development, research, monitoring and evaluation, implementation, and advocacy and communication at national, regional, and global levels [4, 5, 8].

Sub-Saharan Africa (SSA)’s populations on average consume more than the recommended sodium intake of 2 g/day [9, 10]. Regrettably, earlier reviews found no national salt reduction initiatives in SSA, with more recent reports finding few existing national-level policies aimed at reducing sodium intake in Nigeria, Mauritius, and South Africa [1015]. Nigeria’s guidelines on salt intake are broad, advising individuals to limit their intake of salt and bouillon cubes [12]. In Mauritius, a national target to reduce the average sodium intake to 5 g/day, and a strategy centred on food labelling exist as part of the country’s CVD reduction strategy [13]. In 2013, South Africa produced a national strategy to reduce salt intake through mandatory reformulation, which would impact the salt content of processed food and help fight the rising burden of hypertension [14]. While these few and recent developments demonstrate some progress in this area, no national action is being taken towards dietary salt intake reduction in the vast majority of SSA. Additionally, there is no evidence of the effectiveness of the existing national salt reduction policies and interventions.

It is important to note that the types of salt reduction interventions that have been successful in higher income countries may be less effective in LMICs owing to contextual differences [1618]. It is therefore imperative that before further development and implementation of national policies on salt reduction in SSA, that effectiveness of existing sub-national interventions in this region is examined. Consequently, the objective of this review was to investigate salt reduction interventions conducted in SSA that have been evaluated, and the results published in scientific journals.

Methods

Search Strategy, Inclusion and Exclusion Criteria

MEDLINE and google scholar were searched using comprehensive search terms on March 2nd 2015 as shown in Table 1. No date limits were set for the MEDLINE search; however, the google scholar search was restricted to articles published in 1960 onwards. No language or age limits were set for either database. Titles and abstracts of the articles were screened by two independent reviewers, and full text copies obtained for articles meeting the initial screening criteria. Full text articles were then screened in duplicate for inclusion in the review. Studies were included if they reported the results of an evaluation of a salt reduction intervention in a population in SSA. Studies were excluded if the results of an evaluation were not reported, and if the population of interest was not from SSA. Reference lists of included studies were also searched to identify any studies that may have been missed in the initial search. This review is registered with the international prospective register of systematic reviews PROSPERO network, under registration number CRD42015019055.

Data Extraction, Quality Assessment, and Synthesis

Data was extracted from included studies into a spreadsheet under the following headings: author(s), year of publication, year of data collection, country, WHO pillar of intervention(s) (product reformulation, consumer awareness and education, or environmental change), study design, population, intervention, control, outcome measures reported, and results. Data on systolic and diastolic blood pressure, mean arterial pressure (in mmHg) and 24h urinary sodium (in mmol/24h) were extracted, including baseline measurements and results post-intervention, where these were reported. Due to the heterogeneity of study designs, quality was assessed using the quality assessment tool for quantitative studies developed by the Effective Public Health Practice Project [19]. A narrative synthesis of the findings was then undertaken.

Results

Fig 1 shows the PRISMA flow diagram with number of included and excluded studies. A total of 2057 records were identified through the MEDLINE and google scholar databases. Following de-duplication and an initial title and abstract screening process, 14 articles were retrieved for full-text review. Of the 14 articles, eight papers reporting on seven individual studies, were included in this systematic review.

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Fig 1. PRISMA Flow Diagram showing inclusion and exclusion of identified papers.

From: Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLos Med 6(6): e1000097. doi: 10.1371/journal.pmed1000097 For more information, visit www.prisma-statement.org.

https://doi.org/10.1371/journal.pone.0149680.g001

As shown in Table 2, four countries, including South Africa, Nigeria, Ghana, and Tanzania, were represented in these seven studies. The earliest paper was published in 1990 and the most recent published in 2013. The studies include a range of study designs including one cluster randomised controlled trial (RCT), with villages used as clusters; two RTCs; one random cross-over trial (participants on three weeks of low/high salt, two weeks wash-out, and then three weeks on low/high salt); one observational study; and, two studies with no contemporaneous control group (before and after studies). Three studies were of weak quality, and the remainder were moderate. There were no studies designated as high quality in this review.

As shown in Table 3, two studies examined product reformulation [20, 21]. In both studies, the reformulated products were provided to the participants. The RCT by Charlton and colleagues (2008) in hypertensive patients found a significant reduction in systolic blood pressure by 6.2 mmHg, as shown in Table 4, but no corresponding change in diastolic blood pressure or 24 hour urinary sodium excretion. It is noteworthy that in this study, besides sodium concentration reformulation, potassium, magnesium and calcium concentrations were also reformulated (increased) in the products [20]. In the RCT by Mtabaji and colleagues (1990), conducted in normotensive volunteers, a reduction in 24 hour urinary sodium excretion and mean arterial blood pressure (of 6mmHg, p<0.001) was found after 4 to 5 days on the low sodium diet; however, this study was assessed as weak in quality, since a study population of volunteers is not likely to represent a general population and the control arm were given supplementary sodium rather than being on a normal diet. There was also no indication that the study was blinded, and no description on how urinary analysis was determined to be valid or reliable [21].

Four studies examined consumer awareness interventions in rural or semi-rural settings [2225] [Table 3]. Two studies were resource intensive, including one before and after cohort study by Cappuccio and colleagues (2000), which examined the effectiveness of daily and weekly lessons with participants, and the second, also a before and after cohort study, by Adeyemo and colleagues (2002), which involved one-on-one counselling to help identify participants’ main sources of dietary sodium and modifying behaviour for reductions in salt intake. Both interventions reported a reduction in the mean 24 hour urinary sodium excretion and systolic blood pressure of 6.4mmHg [22] and 4.7mmHg in men and 7.0 mmHg in women [23] [Table 4]). Two studies were less resource intensive; the first, a cluster RCT involving hour-long health advice sessions on salt reduction delivered by community health workers to whole villages daily for one week, and then once a week thereafter, in addition to standard health messaging [24]. The second, a randomised cross-over trial, involving a counselling and food tasting session to teach participants how to reduce salt added during cooking by half and how to eliminate the use of bouillon cubes and monosodium glutamate seasoning for a 2-week period [25]. The first study found a reduction in diastolic blood pressure (4.0mmHg) following the intervention, while the second found a reduction in systolic (4.5mmHg) and diastolic (2.7mmHg) blood pressure as well as urinary sodium [Table 4], although both were assessed as weak in quality the former due to vulnerability to selection bias, lack of intervention integrity (possible contamination) and blinding and the latter also due to selection bias and failure to blind participants and researchers.

Finally, an observational study, reported in two papers, examined environmental change [26, 27] [Table 3]. Members of a life and health insurance scheme who had signed up to receive this benefit received a 10% discount on healthy food purchases, or a 25% discount if they completed a health risk assessment questionnaire online. Discount recipients were then compared to regular members with the finding that discount holders spent more on healthy foods as a proportion of total food expenditure, and less on unhealthy food. They also reported eating healthier foods more often, and unhealthy foods (including salty food, processed meat, fast-food and fried food) less often. These papers did not report any individual health outcomes such as blood pressure measurements or urinary sodium.

Discussion

The objective of this review was to investigate salt reduction interventions conducted in SSA that have been evaluated, with results published. A search of the MEDLINE and google scholar databases yielded eight articles, representing seven studies, for inclusion in the analyses. Considered the gold-standard for inclusion in systematic reviews, 3 of the studies were RCTs; however, given the limited evidence available, observational studies and other research designs were also included. Due to the small number of studies identified and their diverse nature with respect to study design, intervention, population and outcomes reported, it was not possible to undertake a meta-analyses, which limits the strength of the conclusions that can be drawn.

The product reformulation interventions resulted in reduction of systolic blood pressure [20], 24h urinary sodium excretion [21], and mean arterial pressure [21]. It is important to note that the food items selected for reformulation were commonly consumed foods, delivered to the end user. For an effective population-wide intervention, product reformation of a select number of products that are commonly used by virtually all members of a nation, may be the best approach. States would have to approach this in consultation with key players in their respective food industries, and channel resources towards monitoring product changes and consumer salt intake, as well as evaluation of successes. Customer awareness and education interventions resulted in a reduction in 24 hour urinary sodium excretion [22, 23, 25], systolic blood pressure [22, 23, 25], and diastolic pressure [23, 24, 25]. Individual and group educational sessions and counselling on salt reduction techniques during cooking and limiting salty food intake outside the home, were effective in improving some key outcomes. One important feature of all the included studies was that while the education or counselling sessions were done intensively at first, they all required an extent of follow-up to reinforce the learnings, typically lasting 2 weeks or more. It is also interesting to note that all the consumer awareness and education interventions captured in this review were conducted in rural populations. Rapid urbanisation in SSA has resulted in a vast change in the demographic landscape of the continent with a projected population increase of 0.9 billion by 2050 [28, 29]. Changing dietary habits, proliferation of high-salt content fast foods, and use of preservatives may lead to a growing number of urban dwellers consuming more salt than their rural counterparts [16, 17]. It is therefore imperative that such salt reduction interventions be tested in urban areas. The environmental change intervention, achieved through subsidies on healthy food purchases, led to higher spending on and eating of healthy foods, and consequently lower spending and eating unhealthy and high salt content foods [26, 27].

All the interventions had at least one significantly improved outcome measure; however, it is important to consider the possibility of publication bias, resulting from interventions with no significant health benefits being unreported. Taken together, while 24 hour urinary sodium excretion was reduced in half of the included studies, blood pressure, and most frequently systolic blood pressure, was reduced in all studies in which it was reported. This may suggest that assessment of 24 hour urinary sodium excretion is associated with greater measurement error. Alternatively, it could mean that blood pressure, even in normotensive individuals, may be more sensitive to changes in salt intake. Systolic hypertension is the most common form of hypertension especially in older age groups, systolic blood pressure is almost always less well controlled than diastolic blood pressure, and it has been argued that reduction in systolic blood pressure is more clinically relevant, particularly among the highest risk and older hypertensive patients [3032].

Conclusions

Since 2007, the WHO has supported development of national salt reduction strategies by establishing networks and partnerships with regional organisations around the world [3335]; however, few African countries have national strategies in place to address salt intake [1015]. Evaluation of high quality studies on salt reduction interventions in the region is also lacking. To attain effective population-wide salt reduction interventions and have larger impact, it is important that policy development target supply chain and main sources of dietary sodium, rather than individual level behaviour change [36]. The former are also less resource intensive per person, and have greater reach. We found only two studies in this category [20, 21], one of which was designated as weak in quality. The majority of studies focused on customer awareness and education, with less promise for scale-up across a vast and diverse continent. One study used financial incentives rather than education to achieve individual-level change and may potentially have broader reach than consumer education. Indeed, comparative cost-effectiveness assessments of these interventions would identify the most viable and affordable option for states in the region. Given the ongoing rapid urbanisation in SSA, it is crucial that such interventions and evaluations be conducted among urban residents, to curb growth in the prevalence of risk factors for, and CVDs.

Acknowledgments

RJL and OO are part supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) West Midlands. Views expressed are those of the authors and not necessarily those of any funding body or the NHS. The funders had no role in any aspect of the manuscript.

Author Contributions

Conceived and designed the experiments: OO. Performed the experiments: OO SKM. Analyzed the data: OO SKM. Wrote the paper: OO SKM SOO RJL.

References

  1. 1. World Health Organisation. (2011). Global status report on noncommunicable diseases 2010: description of the global burden of NCDs, their risk-factors and determinants. Geneva: WHO.
  2. 2. Mozaffarian D, Fahimi S, Singh GM, Micha R, Khatibzadeh S, Engell RE, et al. Global sodium consumption and death from cardiovascular causes. The New England journal of medicine. 2014 Aug;371(7):624–634. Available from: http://view.ncbi.nlm.nih.gov/pubmed/25119608. pmid:25119608
  3. 3. Lawes CM, Vander Hoorn S, Law MR, Elliott P, MacMahon S, Rodgers A. Blood pressure and the global burden of disease 2000. Part 1: estimates of blood pressure levels. J Hypertens. 2006 Mar;24(3):413–22. pmid:16467639.
  4. 4. World Health Organization. (2008). 2008–2013 Global action plan for the prevention and control of NCDs. Geneva: WHO. http://whqlibdoc.who.int/publications/2009/9789241597418_eng.pdf, accessed
  5. 5. World Health Organization. (2004). Global Strategy on Diet, Physical Activity and Health. Geneva: WHO. http://www.who.int/dietphysicalactivity/strategy/eb11344/en/indexhtml, accessed
  6. 6. World Health Organization. (2010). Creating an enabling environment for population-based salt reduction strategies: report of a joint technical meeting held by WHO and the Food Standards Agency, United Kingdom. 2013–2020. Geneva: WHO.
  7. 7. World Health Organization. (2010). Strategies to monitor and evaluate population sodium consumption and sources of sodium in the diet: report of a joint technical meeting convened by WHO and the Government of Canada. Geneva: WHO.
  8. 8. World Health Organization. (2010). Salt reduction and iodine fortification strategies in publis health: report of a joint technical meeting convened by WHO and the George Institute for Global Health in collaboration with the International Council for the Control of Iodine Deficiency Disorders Global Network, Australia. Geneva: WHO.
  9. 9. Brown IJ, Tzoulaki I, Candeias V, Elliott P. Salt intakes around the world: implications for public health. Int J Epidemiol. 2009 Jun;38(3):791–813. pmid:19351697.
  10. 10. Oyebode O, Oti S, Chen Y-F, Lilford RJ. Salt intakes in sub-Saharan Africa: a systematic review and meta-regression. 2016. Jan, 14: 1.
  11. 11. Webster JL, Dunford EK, Hawkes C, Neal BC. Salt reduction initiatives around the world. Journal of Hypertension. 2011 Jun;29(6):1043–50. pmid:21546876
  12. 12. World Health Organization. (2006). Reducing salt intake in populations: report of a WHO forum and technical meeting. Geneva: WHO. http://www.who.int/dietphysicalactivity/Salt_Report_VC_april07.pdf)
  13. 13. Mezue K. The increasing burden of hypertension in Nigeria—can a dietary salt reduction strategy change the trend? Perspectives in Public Health. 2014 Nov;134(6):346–52. Epub 2013 Sep 3. pmid:24002906
  14. 14. Lachat C, Otchere S, Roberfroid D, Abdulai A, Seret FM, Milesevic J et al. Diet and physical activity for the prevention of noncommunicable diseases in low- and middle-income countries: a systematic policy review. PLoS Medicine. 2013;10(6):e1001465. Epub 2013 Jun 11. pmid:23776415
  15. 15. Hofman KJ, Tollman SM. Population health in South Africa: a view from the salt mines. Lancet Global Health. 2013 Aug;1(2):e66–7. Epub 2013 Jul 5. pmid:25104152
  16. 16. Trieu K, Neal B, Hawkes C, Dunford E, Campbell N, Rodriguez-Fernandez R et al. Salt reduction initiatives around the world—a systematic review of progress towards the global target. PLoS ONE 2015;10(7):e0130247. pmid:26201031
  17. 17. Cappuccio FP. Epidemiologic transition, migration and cardiovascular disease. Int J Epidemiol 2004; 33: 387–8 pmid:15082646
  18. 18. Gomez GB & Cappuccio FP. Dietary salt and disease prevention: a global perspective. Curr Med Chem—Immun Endoc & Metab Agents 2005; 5: 13–20.
  19. 19. Effective Public Health Practice Project (EPHPP). Quality assessment tool for quantitative studies. Available at http://www.ephpp.ca/tools.html
  20. 20. Charlton KE, Steyn K, Levitt NS, Peer N, Jonathan D, Gogela T et al. A food-based dietary strategy lowers blood pressure in a low socio-economic setting: a randomised study in South Africa. Public Health Nutrition: 11(12), 1397–1406 pmid:18752692
  21. 21. Mtabaji JP, Nara Y, Yamori Y. The cardiac study in Tanzania: salt intake in the causation and treatment of hypertension. Journal of Human Hypertension (1990) 4, 80–81. pmid:2338696
  22. 22. Adeyemo AA, Prewitt TE, Like A, Omoade OO, Rotimi CN, Brieger WR et al. Feasibility of implementing a dietary sodium reuduction intervention among free-living normotensive individuals in South West Nigeria. Ethinicity and Disease, 2002;12:207–212.
  23. 23. Cappuccio FP, Plange-Rhule J, Phillips RO, Eastwood JB. Prevention of hypertension and stroke in Africa. Lancet, 356, August 19, 2000
  24. 24. Cappuccio FP, Kerry SM, Micah FB, Plange-Rhule J, Eastwood JB. A community programme to reduce salt intake and blood pressure in Ghana. BMC Public Health 2006, 6:13. pmid:16433927
  25. 25. Forrester T, Adeyemo A, Soarres-Wynter S, Sargent L, Bennett F, Wilks R et al. A randomized trial on sodium reduction in two developing countries. Journal of Human Hypertension (2005) 19, 55–60. pmid:15470483
  26. 26. An R, Patel D, Segal D, Sturm R. Eating better for less: a national discount program for healthy food purchases in South Africa. Am J Health Behav. 2013 January; 37(1): 56–61. pmid:22943101
  27. 27. Sturm R, An R, Segal D, Patel D. A cash-back rebate program for healthy food purchases in South Africa: results from scanner data. Am J Prev Med. 2013 June; 44(6): 567–572. pmid:23683973
  28. 28. African development bank group. (Dec 2012). Urbanization in Africa. Available at http://www.afdb.org/en/blogs/afdb-championing-inclusive-growth-across-africa/post/urbanization-in-africa-10143/
  29. 29. UN Department of Economic and Social Affairs, Population Division. World Urbanization Prospects, the 2011 Revision. Available at http://esa.un.org/unup/
  30. 30. Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, Julius S, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomized trial. Lancet. 1998;351:1755–1762. pmid:9635947
  31. 31. Izzo JL, Levy D, Black HR. Clinical Advisory Statement: Importance of Systolic Blood Pressure in Older Americans. Available at http://www.nhlbi.nih.gov/health-pro/resources/heart/blood-pressure-clinical-advisory-1999-html
  32. 32. Neaton JD, Wentworth D. Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease: overall findings and differences by age for 316,099 white men. Multiple Risk Factor Intervention Trial Research Group. Arch. Intern. Med. 1992;152:56–64. pmid:1728930
  33. 33. Penney S. Dropping the Salt: practical steps countries are taking to prevent chronic noncommunicable diseases through population-wide dietary salt reduction. Canada: Public Health Agency of Canada, Pan American Health Organisation, CARMEN;2009.
  34. 34. Webster J. Salt reduction in the Western Pacific Region: strategies for action. http://www.georgeinstitute.org/global-health-landscape
  35. 35. World Health Organisation Regional Office For Europe. WHO European action plan for food and nutrition policy 2007–2012: Action Networks. 2008; http://www.euro.who.int/nutrition/ActionPlan/20080516_1.
  36. 36. Brown IJ, Tzoulaki I, Candeias V, Elliott P. Salt intakes around the world: implications for public health. Int J Epidemiol. 2009 Jun;38(3):791–813. pmid:19351697.