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Correction: Lycopene and Beta-Carotene Induce Growth Inhibition and Proapoptotic Effects on ACTH-Secreting Pituitary Adenoma Cells

  • Natália F. Haddad,
  • Anderson J. Teodoro,
  • Felipe Leite de Oliveira,
  • Nathália Soares,
  • Rômulo Medina de Mattos,
  • Fábio Hecht,
  • Rômulo Sperduto Dezonne,
  • Leandro Vairo,
  • Regina Coeli dos Santos Goldenberg,
  • Flávia Carvalho Alcântara Gomes,
  • Denise Pires de Carvalho,
  • Mônica R. Gadelha,
  • Luiz Eurico Nasciutti,
  • Leandro Miranda-Alves

Correction: Lycopene and Beta-Carotene Induce Growth Inhibition and Proapoptotic Effects on ACTH-Secreting Pituitary Adenoma Cells

  • Natália F. Haddad, 
  • Anderson J. Teodoro, 
  • Felipe Leite de Oliveira, 
  • Nathália Soares, 
  • Rômulo Medina de Mattos, 
  • Fábio Hecht, 
  • Rômulo Sperduto Dezonne, 
  • Leandro Vairo, 
  • Regina Coeli dos Santos Goldenberg, 
  • Flávia Carvalho Alcântara Gomes
PLOS
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The authors would like to correct Fig 2A and Fig 4. In Fig 2A, while preparing the figure for publication, the same image was erroneously used for the Lycop 5 μM plate and the beta-carot 10μM plate. The authors have provided a corrected version of Fig 2, which includes the correct image for the Lycop 5 μM plate. In Fig 4, while preparing the figure for publication, the same image was erroneously used for the Lycop 5μM flow cytometry plot and the beta-carot 5μM plot. The authors have provided a corrected version of Fig 4, which includes the correct image for the beta-carot 5μM plot. The underlying data and unedited images for Fig 2A and Fig 4 are available as Supporting Information. The authors confirm that these errors do not alter their results.

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Fig 2. Formation of AtT-20 colonies.

The number of AtT-20 colonies was determined after 21 days of culture in DMEM supplemented with 10% FCS containing lycopene (Lycop) and beta-carotene (beta-carot) at concentrations of 5 and 10 μM. The number of colonies formed was detected by crystal violet staining. Phase contrast microscopy of AtT-20 cell colonies was observed on 6-well culture plates (A) and quantitative representation of the colonies formed (B). Data are presented as mean±standard deviation of 3 independent experiments, each performed at least in duplicate. *indicates significant differences from control group (**p<0.01, ***p<0.001).

https://doi.org/10.1371/journal.pone.0149157.g001

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Fig 4. Detection of apoptotic AtT-20 cells by flow cytometry under lycopene or beta-carotene stimulation at the concentrations of 5 and 10 μM for 96 h.

When the cells were treated with lycopene and carotene, the apoptosis rate increased significantly at concentrations of 5 and 10 μM. Beta-carotene at 10 μM induced a greater increase in the rate of apoptosis compared with the other experimental conditions. Data are expressed as mean±standard deviation relative to the control, of 3 independent experiments, each performed with at least 3 replicates. *indicates significant differences from control group (*p<0.05, **p<0.01, ***p<0.001).

https://doi.org/10.1371/journal.pone.0149157.g002

Supporting Information

S1 Data and Images. The underlying data and unedited images for Fig 2A and Fig 4.

https://doi.org/10.1371/journal.pone.0149157.s001

(ZIP)

Reference

  1. 1. Haddad NF, Teodoro AJ, Leite de Oliveira F, Soares N, de Mattos RM, Hecht F, et al. (2013) Lycopene and Beta-Carotene Induce Growth Inhibition and Proapoptotic Effects on ACTH-Secreting Pituitary Adenoma Cells. PLoS ONE 8(5): e62773. pmid:23667519