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Correction: Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies

  • Xiangying Guan,
  • Ping Lin,
  • Eric Knoll,
  • Raj Chakrabarti

Correction: Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies

  • Xiangying Guan, 
  • Ping Lin, 
  • Eric Knoll, 
  • Raj Chakrabarti
PLOS
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Correction

14 Sep 2015: The PLOS ONE Staff (2015) Correction: Correction: Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies. PLOS ONE 10(9): e0138393. https://doi.org/10.1371/journal.pone.0138393 View correction

The authors would like to provide the expressions for K1,K2,K3, Km,NAD+ and vmax for Equation 3, which should have been included as a supplementary file with the article.

The expressions for K1,K2,K3,Km,NAD+ and vmax are provided in S1 File in this Correction.

For sirtuins, kcat<< kj, j ≠ cat does not imply Km, NAD+ ≈ Kd, NAD+; see S1 File.

Supporting Information

S1 File. Initial rate model for sirtuin deacetylation kinetics.

https://doi.org/10.1371/journal.pone.0136127.s001

(PDF)

Reference

  1. 1. Guan X, Lin P, Knoll E, Chakrabarti R (2014) Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies. PLoS ONE 9(9): e107729. pmid:25221980