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Correction: Effects of Chronic Fluoxetine Treatment on Neurogenesis and Tryptophan Hydroxylase Expression in Adolescent and Adult Rats

  • Anne Klomp,
  • Lena Václavů,
  • Gideon F. Meerhoff,
  • Liesbeth Reneman,
  • Paul J. Lucassen

Correction: Effects of Chronic Fluoxetine Treatment on Neurogenesis and Tryptophan Hydroxylase Expression in Adolescent and Adult Rats

  • Anne Klomp, 
  • Lena Václavů, 
  • Gideon F. Meerhoff, 
  • Liesbeth Reneman, 
  • Paul J. Lucassen
PLOS
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There are errors in Fig 3. Please see the complete, correct Fig 3 here.

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Fig 3. Age-related effects of fluoxetine and regional differences in cell differentiation.

An example of doublecortin (DCX) expression along the subgranular zone is shown for adult-treated (A) and adolescent-treated rats (B). C) Two-Way ANOVA revealed both a significant age-by-treatment interaction effect (p = 0.036) and a significant effect of age (p < 0.001) on the expression of DCX+ cells. D) There were regional differences in the amount of DCX+ cells. There was a significant effect of age in all sub-regions (p < 0.001), a significant treatment effect in the ventral infrapyramidal blade of the dentate gyrus (p = 0.021), and a significant age-by-treatment interaction effect in the dorsal infrapyramidal blade (p = 0.028). E) There was both a significant effect of age (p = 0.017) as well as a main effect of treatment (p = 0.045) on dentate gyrus volume. Dentate gyrus volume comprised the SGZ plus GCL. $ = main effect of age; = main effect of treatment; # = age-by-treatment effect. P-values below 0.050 were considered statistically significant. Error bars indicate ± 1 S.E.M.

https://doi.org/10.1371/journal.pone.0135876.g001

Reference

  1. 1. Klomp A, Václavů L, Meerhoff GF, Reneman L, Lucassen PJ (2014) Effects of Chronic Fluoxetine Treatment on Neurogenesis and Tryptophan Hydroxylase Expression in Adolescent and Adult Rats. PLoS ONE 9(5): e97603. pmid:24827731