Various efficacies of anti-CD3 intervention have been administered at day 4, which corresponds with encephalitogenic T cell priming. (A) Median effector T cell peak population sizes. (B) CD4Th1 population sizes at 40 days post-induction of EAE; red and blue bars indicate large and non-large effect magnitude changes with respect to the control group, in black. (C) Proportion of simulations that reach a particular maximum clinical disease score. A-test effect magnitude levels are given: 1, 2 and 3 *'s represent small, medium and large effects respectively. (D & E) Proportion of simulations contracting particular clinical scores or greater over time, for control (D) and a drug efficacy of 80% (E).
Citation: Read M, Andrews PS, Timmis J, Williams RA, Greaves RB, Sheng H, et al. (2015) Correction: Determining Disease Intervention Strategies Using Spatially Resolved Simulations. PLoS ONE 10(5): e0128170. doi:10.1371/journal.pone.0128170
Published: May 8, 2015
Copyright: © 2015 Read et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited