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Correction: Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells

  • Trent Fowler,
  • Payel Ghatak,
  • David H. Price,
  • Ronald Conaway,
  • Joan Conaway,
  • Cheng-Ming Chiang,
  • James E. Bradner,
  • Ali Shilatifard,
  • Ananda L. Roy

Correction: Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells

  • Trent Fowler, 
  • Payel Ghatak, 
  • David H. Price, 
  • Ronald Conaway, 
  • Joan Conaway, 
  • Cheng-Ming Chiang, 
  • James E. Bradner, 
  • Ali Shilatifard, 
  • Ananda L. Roy
PLOS
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There is an error in Fig 2 that appears to have occurred during the preparation of files after the manuscript was accepted. In Fig 2B, the blot for Brd4 incorrectly appears as a duplicate of P-Brd4. The authors have provided a corrected version of Fig 2 here.

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Fig 2. Brd4 occupancy and expression in different cells.

Cells were either untreated or treated with 1 μM of JQ1 for 2 hours. (A) Chromatin Immunoprecipitation (ChIP) across MYC with anti-C-terminal Brd4 antibody. Each experiment was performed twice, analyzed in triplicate via real-time PCR and reported as the mean and standard deviation of the two experiments. A representation of the promoter area of MYC is provided for orientation. (B) Western blotting to detect (far left) Brd4 (~180 KD) and (middle) Brd4-S484/488-phos (P-Brd4, ~220 KD) was performed three times. A non-specific band detected with phopsho-Brd4 antibody is denoted with an asterisk. Typical results are shown with densitometry analysis relative to CREB expression, which is used as a normalization control (far right).

https://doi.org/10.1371/journal.pone.0126328.g001

Reference

  1. 1. Fowler T, Ghatak P, Price DH, Conaway R, Conaway J, Cheng-Ming C, et al. (2014) Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells. PLoS ONE 9(1): e87003. pmid:24466310