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Correction: Can Gas Replace Protein Function? CO Abrogates the Oxidative Toxicity of Myoglobin

  • The PLOS ONE Staff

Correction: Can Gas Replace Protein Function? CO Abrogates the Oxidative Toxicity of Myoglobin

  • The PLOS ONE Staff
PLOS
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Figure 9, “Differences in Hb and Mb induced oxidation yield distinct protection mechanisms,” is incorrect. Please see the corrected Figure 9 here.

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Figure 9. Differences in Hb and Mb induced oxidation yield distinct protection mechanisms.

In presence of peroxide, ferrous RH are oxidized to their ferric (FeIII) and/or ferryl (FeIV) forms. Upper: Hp binds Hb (ferrous and/or ferric) thereby preventing its release. Lower: Mb heme is retained attached to globin following oxidation in a peroxidase-like form. However, binding of CO to ferrous Mb prevents its oxidation to a ‘peroxidase-like form”.

https://doi.org/10.1371/journal.pone.0104075.g009

Reference

  1. 1. Sher EA, Sholto AY, Shaklai M, Shaklai N (2014) Can Gas Replace Protein Function? CO Abrogates the Oxidative Toxicity of Myoglobin. PLoS ONE 9(8): e104075