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Correction: Signaling Role of Prokineticin 2 on the Estrous Cycle of Female Mice

  • The PLOS ONE Staff

Correction: Signaling Role of Prokineticin 2 on the Estrous Cycle of Female Mice

  • The PLOS ONE Staff
PLOS
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Figures 2, 5, 6, and 7 are in the incorrect order. The publisher apologizes for these errors. The figure legends are correct. The correct versions of Figures 2, 5, 6, and 7 can be viewed here.

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Figure 2. PKR2 antagonist reduced plasma LH levels (Mean ± S.E.).

The LH levels in the PKR2 antagonist (10 mg/kg 3Cl-MPL) group were significantly reduced compared to the vehicle treatment (n  =  6 for each group, p<0.01.

https://doi.org/10.1371/journal.pone.0090860.g002

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Figure 5. The coexpression of PKR2 and ERα in the preoptic area. PKR2 and ERα were detected by immunofluorescence staining.

PKR2-GFP expression was shown in green and ERα expression was shown in red. Yellow or orange color in the MnPO and AVPV regions indicates likely co-expression of PKR2 and ERα (scale bars:100 µm).

https://doi.org/10.1371/journal.pone.0090860.g005

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Figure 6. Potency of PKR2 antagonist, 3Cl-MPL, in antagonizing PKR2.

Antagonist potency was examined in Chinese Hamster Ovary (CHO) cells that stably express PKR2. RLU is an index for calcium influx measurement with a luminescence-based assay. The IC50 of 3Cl-MPL for PKR2 were 24.9±4.3 nM(Mean ± S.E.). Shown was representative of three independent experiments.

https://doi.org/10.1371/journal.pone.0090860.g006

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Figure 7. Blocking of estrous cycle by PKR2 antagonist treatment.

The administration of 3Cl-MPL (shown in red arrows) prevented the progression to estrous stage. Vehicle treatment was shown by blue arrows. E: estrus, P: proestrus, D: diestrus, M: metestrus.

https://doi.org/10.1371/journal.pone.0090860.g007

Reference

  1. 1. Xiao L, Zhang C, Li X, Gong S, Hu R, et al. (2014) Signaling Role of Prokineticin 2 on the Estrous Cycle of Female Mice. PLoS ONE 9(3): e90860