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Correction: Myelopoietic Efficacy of Orlistat in Murine Hosts Bearing T Cell Lymphoma: Implication in Macrophage Differentiation and Activation

  • The PLOS ONE Staff

Correction: Myelopoietic Efficacy of Orlistat in Murine Hosts Bearing T Cell Lymphoma: Implication in Macrophage Differentiation and Activation

  • The PLOS ONE Staff
PLOS
x

Figure 1, Figure 6, and Equation 1 have been corrected for better readability.

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Figure 1. Protocol for administering orlistat to tumor-bearing mice.

Mice were transplanted DL cells (1x105cells/0.5 ml PBS) on day 0 following administration of Vehicle alone (control) or containing orlistat 240mg/kg body weight/day up to day 14 post tumor transplantation. On day 16 BMC were harvested from femurs.

https://doi.org/10.1371/journal.pone.0082396.g001

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Figure 6. BMDM obtained from BMC of orlistat-administered groups display M1 Mφ phenotype.

BMDM differentiated from BMC of control or orlistat-administered tumor-bearing mice were incubated in vitro for 24h in medium alone or containing IFN- γ (100IU/ml) + LPS (10ng/ml) followed by estimation of NO (a), indicated cytokines by ELISA in culture supernatant (b), assay of ROS expression (d,e), phagocytosis (c), BMDM-mediated tumoricidal activity (f,g) and expression of cell surface functional markers: CD11c and TLR2 (h). Values shown in (a,b,e,f,g) mean ± SD of three independent experiments done in triplicate.*p<0.05 vs. values of respective control. *#p<0.05 vs. values for orlistat and LPS + IFN-γ treated control groups. Arrows indicates increased phagocytosis (c), expression of ROS (d) and CD11c & TLR-2 (h) in BMDM of orlistat group treated with IFN-γ + LPS.

https://doi.org/10.1371/journal.pone.0082396.g002

Figure 1 is incorrect. The authors have provided a corrected version here.

Figure 6 is incorrect. The authors have provided a corrected version here.

Equation 1 is incorrect. The authors have provided a corrected version here.

Reference

  1. 1. Kant S, Kumar A, Singh SM (2013) Myelopoietic Efficacy of Orlistat in Murine Hosts Bearing T Cell Lymphoma: Implication in Macrophage Differentiation and Activation. PLoS ONE 8(12): e82396