Supporting information file containing Figures S1–S7, Tables S1–S4, supplementary methods, and detail descriptions of the tabs in File 2, 3, and 4. Figure S1: Body weight data for mice from 5 to 21 months of age. Figure S2: Food consumption data for mice from 5 to 24 months of age. Table S1: Survival analysis of C57BL/6 mice fed Rapamycin. Table S2: Fitted Gompertz Mortality Models. Table S3: Tissue Weights at 25 months of age. Figure S3: Phosphorylated S6/Total S6 ratio shows no change among all the groups. Figure S4: Gene analysis shows that Rapa-2 males share many genes that change in Rapa Female mice. Figure S5: Validation of genes in the mitochondria dysfunction and estrogen receptor signaling pathways. Table S4: Gene enrichment analysis using DAVID bioinformatics resources. Figure S6: Gene analysis shows significant gene changes in 6-months Rapa female mice. Figure S7: Fibroblasts pretreated with Rapa are more sensitive to oxidative stressors.
Citation: The PLOS ONE Staff (2014) Correction: Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome. PLoS ONE 9(4): e92346. doi:10.1371/journal.pone.0092346
Published: April 1, 2014
Copyright: © 2014 The PLOS ONE Staff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.